| Source: |
| Type: |
| ATFs respond to extracellular signals, indicating their important roles in maintaining homeostasis. The ATF family includes ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7. Consistent with the diversity of cellular processes reported to be regulated by ATFs, the functions of ATFs are also diverse. ATFs play an important role in cell proliferation, apoptosis, differentiation and inflammation-related pathological processes. ATF (Activating Transcription Factor) proteins are a family of transcription factors that play crucial roles in various cellular processes, including stress responses, metabolism, and cell differentiation. In the context of cancer, several ATF family members have been implicated in tumorigenesis, cancer progression, and prognosis. Here are some key points regarding ATFs and their expression in cancers with prognostic implications. ATF3: Often associated with stress responses, ATF3 can have dual roles in cancer. In some contexts, it acts as a tumor suppressor, while in others, it may promote tumor growth. High expression of ATF3 has been linked to poor prognosis in certain cancers, such as breast cancer and pancreatic cancer. ATF4: ATF4 is involved in the integrated stress response and can promote cell survival under stress conditions. Its expression is often elevated in various cancers, including glioblastoma and multiple myeloma, and has been associated with poor prognosis due to its role in promoting survival and resistance to therapy. ATF6: ATF6 is part of the unfolded protein response (UPR) and is involved in maintaining cellular homeostasis. Its expression has been linked to cancer cell survival and may correlate with poor outcomes in certain malignancies. ATF1: ATF1 is involved in regulating genes associated with cell proliferation and survival. Its expression levels can vary in different cancers, and its prognostic significance is still being explored. ATF2: ATF2 has been implicated in both promoting and inhibiting cancer progression, depending on the context. Elevated levels of ATF2 have been associated with poor prognosis in some cancers, such as melanoma. |
| Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression. TP53 is the most commonly mutated gene in human cancer. HH↑, GLI-1↑, SHH↑ P53↓ The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca. It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma. Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer. It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress. Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC. |
| 91- | QC, | The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells |
| - | in-vitro, | Pca, | PC3 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:22 Cells:% prod#:% Target#:485 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid