HSP72 Cancer Research Results

HSP72, Heat Shock Protein 72: Click to Expand ⟱

Source:

Type:

Also known as HSPA1A
HSP72, or Heat Shock Protein 72, is a member of the heat shock protein family, which plays a crucial role in cellular stress responses. It is also known as HSPA1A and is involved in protein folding, protection against stress-induced damage, and the regulation of apoptosis (programmed cell death). HSP72 can help cancer cells survive under stressful conditions, such as those found in the tumor microenvironment (e.g., low oxygen, nutrient deprivation). This ability to protect cells from stress can contribute to tumor growth and resistance to therapy.
Elevated levels of HSP72 have been associated with resistance to various cancer treatments, including chemotherapy and radiation. Cancer cells that express high levels of HSP72 may be more capable of repairing damage caused by these therapies, leading to treatment failure.

Pca, Prostate Cancer: Click to Expand ⟱

Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.

Scientific Papers found: Click to Expand⟱

97-

QC,

HPT,

Effects of the flavonoid drug Quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo

in-vitro,

Pca,

PC3

 0-400 uM; 150mg/kg/day

HSP72↑, TumCG↓, eff↑, ChemoSen↑, RadioS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Protein Folding & ER Stress ⓘ

HSP72↑, 1,

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1, eff↑, 1, RadioS↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: HSP72, Heat Shock Protein 72

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells