Ferritin Cancer Research Results

Ferritin, SF serum Ferritin: Click to Expand ⟱
Source:
Type:
It is widely accepted that there is a strong relationship between iron levels and cancer. . Serum ferritin levels are elevated in many malignancies.
Gynecological malignant tumor patients with high serum ferritin levels have significantly less survival time than patients with low or normal serum ferritin levels.
Ferritin is the primary intracellular iron-storage protein, with small amounts released into circulation. Biologically, ferritin buffers iron to prevent oxidative damage. Clinically, serum ferritin is a composite signal reflecting iron stores and inflammation.

Key point: In cancer, ferritin behaves more like an inflammatory biomarker than a pure iron marker.

In oncology, high ferritin usually reflects one or more of the following:
-IL-6–driven inflammation (acute-phase response)
-Iron sequestration (functional iron deficiency despite high ferritin)
-Tumor-associated macrophage activity
-Cell death and tissue breakdown
-Liver involvement (secondary contributor)

Thus, ferritin integrates immune activation + metabolic stress.


Pca, Prostate Cancer: Click to Expand ⟱
Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.
Scientific Papers found: Click to Expand⟱
8139- LF,    Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis
- vitro+vivo, Pca, NA
Ferroptosis↓, AR↝, Iron↝, Ferritin↑, P53↓, eff↝, other↝, AntiTum↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↓, 1,   Iron↝, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   Ferritin↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Ferritin, SF serum Ferritin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:22  Cells:%  prod#:%  Target#:573  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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