ATF6 Cancer Research Results

ATF6, Activating Transcription Factor 6: Click to Expand ⟱
Source:
Type: protein
ATF6 (Activating Transcription Factor 6) is a protein that plays a crucial role in the unfolded protein response (UPR), a cellular stress response pathway that is activated in response to endoplasmic reticulum (ER) stress.
High ATF6 expression is associated with poor prognosis, including shorter overall survival and increased risk of recurrence.
Pca, Prostate Cancer: Click to Expand ⟱
Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.
Scientific Papers found: Click to Expand⟱
3512- Bor,    Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake
- in-vitro, Pca, DU145
TumCP↓, eIF2α↑, ATF4↑, ATF6↑, GADD34↑, CHOP↓, GRP78/BiP↑, GRP94↑, Risk↓, *BMD↑, Ca+2↓, *Half-Life↝, IRE1∅, chemoP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

GADD34↑, 1,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   CHOP↓, 1,   eIF2α↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   IRE1∅, 1,  

Migration ⓘ

Ca+2↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   Risk↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: ATF6, Activating Transcription Factor 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:22  Cells:%  prod#:%  Target#:861  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page