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| Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression. TP53 is the most commonly mutated gene in human cancer. HH↑, GLI-1↑, SHH↑ P53↓ The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca. It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma. Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer. It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress. Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC. |
| 4620- | Bor, | BTZ, | Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy |
| - | Review, | Var, | NA | - | Review, | Arthritis, | NA | - | Review, | Pca, | NA |
| 5867- | CA, | Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines |
| - | in-vitro, | Pca, | DU145 | - | in-vitro, | Liver, | Hep3B | - | in-vitro, | AML, | K562 | - | in-vitro, | Pca, | PC3 | - | in-vitro, | BC, | MDA-MB-231 |
| 6097- | Chol, | Choline intake and risk of lethal prostate cancer: incidence and survival |
| - | Study, | Pca, | NA |
| 132- | CUR, | Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells |
| - | in-vitro, | Pca, | PC3 |
| 6669- | Deg, | Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells |
| - | vitro+vivo, | Pca, | NA |
| 6383- | Eug, | In Vitro Incorporation of Radioiodinated Eugenol on Adenocarcinoma Cell Lines (Caco2, MCF7, and PC3) |
| - | in-vitro, | Colon, | Caco-2 | - | in-vitro, | BC, | MCF7 | - | in-vitro, | Pca, | PC3 |
| 7337- | Gra, | Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer |
| - | in-vitro, | Pca, | NA |
| 7370- | HibSad, | Hibiscus sabdariffa leaf induces apoptosis of human prostate cancer cells in vitro and in vivo |
| - | vitro+vivo, | Pca, | LNCaP | - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | DU145 |
| 7372- | HOO, | Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent |
| - | in-vitro, | Pca, | PC3 |
| 7738- | isoFl, | Consumption of soy isoflavone enriched bread in men with prostate cancer is associated with reduced pro-inflammatory cytokines and immune suppressive cells |
| - | Trial, | Pca, | NA |
| 7987- | itraC, | Repurposing itraconazole as a treatment for advanced prostate cancer: a noncomparative randomized phase II trial in men with metastatic castration-resistant prostate cancer |
| - | Trial, | Pca, | NA |
| 8013- | itraC, | High-dose itraconazole as a non-castrating therapy for a patient with biochemically-recurrent prostate cancer |
| - | Case Report, | Pca, | NA |
| 7963- | JG, | Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines |
| - | vitro+vivo, | Pca, | LNCaP | - | in-vitro, | Pca, | DU145 |
| 8139- | LF, | Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis |
| - | vitro+vivo, | Pca, | NA |
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
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