PDK1 / PDPK1 Cancer Research Results

PDK1 / PDPK1, Pyruvate dehydrogenase kinase 1: Click to Expand ⟱
Source:
Type:

PDPK1 - 3-Phosphoinositide-Dependent Protein Kinase 1

Abbreviation: PDPK1, PDK1

Type: Serine/threonine protein kinase / PI3K pathway signaling kinase / AGC kinase activator

Function: PDPK1 is a central signaling kinase downstream of phosphoinositide 3-kinase. It phosphorylates and activates multiple AGC-family kinases, including AKT, S6K, SGK, RSK, and selected PKC isoforms, thereby regulating proliferation, survival, metabolism, migration, and cellular growth.

Cancer: ↑ Frequently overexpressed, hyperactivated, or functionally dysregulated in cancer. Increased PDPK1 signaling enhances PI3K-AKT pathway output, proliferation, survival, migration, invasion, metastasis, metabolic adaptation, and resistance to anticancer therapies. Genetic or pharmacological suppression of PDPK1 can inhibit tumor growth and restore treatment sensitivity in experimental models.

Favorable Direction in Cancer: ↓ PDPK1 expression or kinase activity is generally favorable.
RCC, Renal cell Carcinoma: Click to Expand ⟱
Renal cell carcinoma (RCC) is one of the most common malignant tumors of the urinary system, accounting for 80–90% of kidney neoplasms.
The activation of the mTOR pathway has been found in RCC and is correlated with high grade and poor prognostic patient features (41,42).
Scientific Papers found: Click to Expand⟱
2125- TQ,    Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
- in-vitro, RCC, RCC4 - in-vitro, RCC, Caki-1
Hif1a↓, eff↝, uPAR↓, VEGF↓, CAIX/CA9↓, PDK1 / PDPK1↓, GLUT1↓, LDHA↓, Glycolysis↓, e-lactateProd↓, i-ATP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

i-ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CAIX/CA9↓, 1,   Glycolysis↓, 1,   e-lactateProd↓, 1,   LDHA↓, 1,   PDK1 / PDPK1↓, 1,  

Migration(tgid=13) ⓘ

uPAR↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PDK1 / PDPK1, Pyruvate dehydrogenase kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:24  Cells:%  prod#:%  Target#:246  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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