Shh Cancer Research Results

Shh, sonic hedgehog: Click to Expand ⟱

Source:

Type: Hedgehog

Components of Shh pathway (smoothened, patched, Gli1 and Gli2).
Sonic Hedgehog (SHH) is a key signaling protein involved in various developmental processes, including cell growth, differentiation, and tissue patterning. The SHH signaling pathway is crucial during embryonic development, but its dysregulation can lead to several types of cancer.
The SHH pathway is activated when the SHH protein binds to its receptor, Patched (PTCH). This interaction relieves the inhibition of another protein, Smoothened (SMO), leading to the activation of downstream signaling that promotes cell proliferation and survival.

In many cancers, SHH and its downstream signaling components are often overexpressed. This overexpression can lead to increased cell proliferation, survival, and tumor growth.

RCC, Renal cell Carcinoma: Click to Expand ⟱

Renal cell carcinoma (RCC) is one of the most common malignant tumors of the urinary system, accounting for 80–90% of kidney neoplasms.
The activation of the mTOR pathway has been found in RCC and is correlated with high grade and poor prognostic patient features (41,42).

Scientific Papers found: Click to Expand⟱

115-

VitD3,

Vitamin D3 Inhibits Hedgehog Signaling and Proliferation in Murine Basal Cell Carcinomas

in-vivo,

RCC,

in-vivo,

BCC,

HH↓, GLI2↓, Shh↓, Gli1↓, Ki-67↓, TumCP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1, HH↓, 1, Shh↓, 1,

Migration ⓘ

GLI2↓, 1, Ki-67↓, 1, TumCP↓, 1,

Clinical Biomarkers ⓘ

Ki-67↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Shh, sonic hedgehog

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells