Wnt Cancer Research Results

Wnt, Wingless-related integration site: Click to Expand ⟱

Source:

Type:

The Wnt signaling pathway is a complex network of proteins that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and migration. It is particularly important during embryonic development and tissue homeostasis. Dysregulation of the Wnt pathway has been implicated in various cancers, making it a significant area of research in oncology.
Wnt Ligands
Wnt1: Often overexpressed in breast cancer and some types of leukemia.
Wnt Receptors
Frizzled (Fzd) Receptors: Different Fzd receptors (e.g., Fzd1, Fzd2, Fzd7) have been implicated in various cancers:
Fzd1: Overexpressed in colorectal cancer.
Fzd2: Associated with breast cancer and prostate cancer.
Fzd7: Linked to gastric cancer and glioblastoma.

RCC, Renal cell Carcinoma: Click to Expand ⟱

Renal cell carcinoma (RCC) is one of the most common malignant tumors of the urinary system, accounting for 80–90% of kidney neoplasms.
The activation of the mTOR pathway has been found in RCC and is correlated with high grade and poor prognostic patient features (41,42).

Scientific Papers found: Click to Expand⟱

4688-

HNK,

Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling

vitro+vivo,

RCC,

A498

CSCs↓, EMT↓, TumCG↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, PTEN↑, Wnt↓, β-catenin/ZEB1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Akt↓, 1, p‑Akt↓, 1,

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1, EMT↓, 1, mTOR↓, 1, PI3K↓, 1, PTEN↑, 1, TumCG↓, 1, Wnt↓, 1,

Migration ⓘ

β-catenin/ZEB1↓, 1,
Total Targets: 10

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Wnt, Wingless-related integration site

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells