NLRP3 Cancer Research Results

NLRP3, NOD-like receptor pyrin domain-containing protein 3: Click to Expand ⟱

Source:

Type:

NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is a protein that plays a crucial role in the regulation of inflammation and immune responses.
NLRP3 typically has high expression in cancers, with poor prognosis.
For alzheimer's disease:
-NLRP3 is upregulated in Alzheimer's disease (AD)
-NLRP3 is activated in microglia in response to amyloid-β (Aβ) and tau aggregates.
-Promotes tau hyperphosphorylation and spread via inflammation-driven pathways.

RCC, Renal cell Carcinoma: Click to Expand ⟱

Renal cell carcinoma (RCC) is one of the most common malignant tumors of the urinary system, accounting for 80–90% of kidney neoplasms.
The activation of the mTOR pathway has been found in RCC and is correlated with high grade and poor prognostic patient features (41,42).

Scientific Papers found: Click to Expand⟱

3070-

RES,

Resveratrol inhibits tumor progression by down-regulation of NLRP3 in renal cell carcinoma

in-vitro,

RCC,

ACHN

0-100uM

in-vitro,

RCC,

786-O

in-vivo,

NA,

nude mice

TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, NLRP3↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1,

Migration ⓘ

TumCI↓, 1, TumCMig↓, 1, TumCP↓, 1,

Protein Aggregation ⓘ

NLRP3↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: NLRP3, NOD-like receptor pyrin domain-containing protein 3

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells