FTO Cancer Research Results

FTO, Fat mass and obesity-associated protein: Click to Expand ⟱

Source:

Type:

FTO Fat mass and obesity-associated protein

FTO is often upregulated in CSCs, where it:
-promotes stemness
-increases sphere formation
-increases tumor initiation
-induces chemoresistance

High FTO promotes EMT by:
↓ E-cadherin
↑ Vimentin
↑ Slug/Snail signaling
FTO-high tumors show increased invasion and metastatic potential.

RCC, Renal cell Carcinoma: Click to Expand ⟱

Renal cell carcinoma (RCC) is one of the most common malignant tumors of the urinary system, accounting for 80–90% of kidney neoplasms.
The activation of the mTOR pathway has been found in RCC and is correlated with high grade and poor prognostic patient features (41,42).

Scientific Papers found: Click to Expand⟱

5555-

BBM,

Berbamine inhibits cell proliferation and invasion by increasing FTO expression in renal cell carcinoma cells

vitro+vivo,

RCC,

TumCP↓, TumCMig↓, TumCI↓, TumCG↓, toxicity↓, FTO↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,

Migration ⓘ

FTO↑, 1, TumCI↓, 1, TumCMig↓, 1, TumCP↓, 1,

Functional Outcomes ⓘ

toxicity↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: FTO, Fat mass and obesity-associated protein

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells