miR-141 Cancer Research Results

miR-141, miR-141: Click to Expand ⟱
Source:
Type:
miR-141 is a member of the microRNA-200 family, which is involved in the regulation of various cellular processes including proliferation, differentiation, apoptosis, and epithelial-to-mesenchymal transition (EMT). As a non-coding RNA, miR-141 regulates gene expression at the post-transcriptional level by binding to specific target messenger RNAs (mRNAs).

miR-141 plays a role in the regulation of EMT by targeting key transcription factors or other EMT-related genes. Its regulation can thus indirectly influence cell adhesion, migration, and invasion.

Both upregulation and downregulation of miR-141 have been reported, with its expression pattern often being context-dependent and linked to the stage and molecular subtype of the tumor.
RCC, Renal cell Carcinoma: Click to Expand ⟱
Renal cell carcinoma (RCC) is one of the most common malignant tumors of the urinary system, accounting for 80–90% of kidney neoplasms.
The activation of the mTOR pathway has been found in RCC and is correlated with high grade and poor prognostic patient features (41,42).
Scientific Papers found: Click to Expand⟱
1120- HNK,    Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling
- vitro+vivo, RCC, NA
EMT↓, CSCs↓, TumCG↓, miR-141↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   TumCG↓, 1,  

Migration ⓘ

miR-141↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-141, miR-141
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:24  Cells:%  prod#:%  Target#:816  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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