MLKL Cancer Research Results

MLKL, Mixed Lineage Kinase Domain-Like: Click to Expand ⟱
Source:
Type:
MLKL (Mixed Lineage Kinase Domain-Like) is a protein that plays a crucial role in necroptosis, a form of programmed cell death.
MLKL is a key mediator of necroptosis, and its expression is often associated with the activation of necroptotic pathways.

MLKL is often downregulated or silenced in various types of cancer. Its downregulation is often associated with tumor progression and poor prognosis.
RCC, Renal cell Carcinoma: Click to Expand ⟱
Renal cell carcinoma (RCC) is one of the most common malignant tumors of the urinary system, accounting for 80–90% of kidney neoplasms.
The activation of the mTOR pathway has been found in RCC and is correlated with high grade and poor prognostic patient features (41,42).
Scientific Papers found: Click to Expand⟱
988- EMD,    Emodin Induced Necroptosis and Inhibited Glycolysis in the Renal Cancer Cells by Enhancing ROS
- in-vitro, RCC, NA
Necroptosis↑, p‑RIP1↑, MLKL↑, ROS↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,  

Cell Death ⓘ

Akt↓, 1,   MLKL↑, 1,   Necroptosis↑, 1,   p‑RIP1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MLKL, Mixed Lineage Kinase Domain-Like
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:24  Cells:%  prod#:%  Target#:943  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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