Database Query Results : , ,

SCC, Squamous Cell Carcinoma: Click to Expand ⟱
Squamous Cell Carcinoma: Also known as epidermoid carcinomas, comprise a number of different types of cancer that begin in squamous cells. These cells form on the surface of the skin.
Scientific Papers found: Click to Expand⟱
2435- 2DG,    Targeting hexokinase 2 for oral cancer therapy: structure-based design and validation of lead compounds
- in-vitro, SCC, CAL27
MMP↓, HK2↓,
263- ALA,    Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines
- in-vitro, SCC, Jurkat - in-vitro, SCC, FaDu
p27↑,
314- Api,    Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis
- in-vitro, SCC, HaCaT - in-vitro, SCC, SCC25
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK1/2/5/9∅,
419- Api,    Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line
- in-vitro, SCC, HN30 - in-vitro, SCC, HN8
CD44↓, Nanog↓, Endoglin↓, VEGF↓, CSCs↓,
1250- Bif,    Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12
- in-vitro, SCC, NA
TumCG↓, Apoptosis↑, CCL20↑, IL12↑,
817- GAR,    Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways
- vitro+vivo, SCC, KYSE150 - vitro+vivo, SCC, KYSE450
HATs↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, CBP↓, p300↓, TGF-β↓, Ki-67↓, SMAD2↓, SMAD3↓,
793- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC9 - in-vitro, SCC, SCC4 - in-vitro, SCC, SCC25
TumCG↓, Apoptosis↑, TumCCA↑, NF-kB↓, COX2↓, VEGF↓,
789- GE,    Complete remission of pulmonary spindle cell carcinoma after treatment with oral germanium sesquioxide
- Case Report, SCC, NA
Remission↑,
840- Gra,    Evaluation of cytotoxicity of aqueous extract of Graviola leaves on squamous cell carcinoma cell-25 cell lines by 3-(4,5-dimethylthiazol-2-Yl) -2,5-diphenyltetrazolium bromide assay and determination of percentage of cell inhibition at G2M phase of cell cycle by flow cytometry: An in vitro study
- in-vitro, SCC, SCC25
TumCCA↑, ATP↓,
2875- HNK,    Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, SCC, H226
HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,
4527- MAG,    Magnolol inhibits growth and induces apoptosis in esophagus cancer KYSE-150 cell lines via the MAP kinase pathway
- in-vitro, ESCC, TE1 - in-vitro, ESCC, Eca109 - vitro+vivo, SCC, KYSE150
TumCP↓, TumCMig↓, MMP2↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑p38↓, TumCG↓,
2378- MET,    Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway
- in-vitro, SCC, CAL27 - in-vivo, NA, NA
TumCP↓, TumCMig↓, TumCI↓, EMT↓, mTOR↓, Hif1a↓, PKM2↓, STAT3↓, E-cadherin↑, Vim↓, Snail↓, STAT3↓,
1066- MET,    Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma
- in-vitro, SCC, NA
PDH↑, Hif1a↓, TumCMig↓, Casp3↑, P53∅,
1891- MGO,    Methylglyoxal induces mitochondria-dependent apoptosis in sarcoma
- in-vitro, SCC, NA
NADH↓, MMP↓, Cyt‑c↑, selectivity↑, Apoptosis↑, ROS↑, ATP↓,
1679- PBG,    Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27)
- in-vitro, SCC, CAL27
tumCV↓, P53↑, Casp9↑, Casp3↑, GSH↓, proline↓,
4933- PEITC,    Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
- vitro+vivo, Lung, H1299 - vitro+vivo, SCC, H226
AntiCan↓, TumCP↓, TumMeta↓, ChemoSen↑, tumCV↓, TumCI↓, TumCMig↓, FTO↓, TLE1↓, Akt↓, NF-kB↓,
362- SNP,    Comparative and Mechanistic Study on the Anticancer Activity of Quinacrine-Based Silver and Gold Hybrid Nanoparticles in Head and Neck Cancer
- vitro+vivo, SCC, SCC9
DNAdam↑, TumVol↓,
4835- Uro,    Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway
- in-vitro, SCC, NA
TumCD↑, ER Stress↑, Akt↓, mtDam↓, p‑mTOR↓, *BioAv↝, ROS↑, TumCCA↑, Apoptosis↑, ERK↓,
1216- VitC,    Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer
- in-vitro, Laryn, FaDu - in-vitro, SCC, SCC-154
Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 2,   Iron↝, 1,   MDA↑, 1,   NADH↓, 1,   ROS↑, 4,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   MMP↓, 2,   mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

HK2↓, 1,   PDH↑, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 6,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   CBP↓, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 1,   p27↑, 1,   p‑p38↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   TLE1↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   P53∅, 1,  

Cell Cycle & Senescence ⓘ

CDK1/2/5/9∅, 1,   CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   CSCs↓, 1,   EMT↓, 1,   ERK↓, 1,   HDAC↓, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   Nanog↓, 1,   p300↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   TumCG↓, 3,  

Migration ⓘ

E-cadherin↑, 1,   FTO↓, 1,   Ki-67↓, 2,   MMP2↓, 1,   proline↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 3,   TumCMig↓, 5,   TumCP↓, 3,   TumMeta↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

Endoglin↓, 1,   Hif1a↓, 2,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

CCL20↑, 1,   COX2↓, 1,   IL12↑, 1,   NF-kB↓, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

Ki-67↓, 2,  

Functional Outcomes ⓘ

AntiCan↓, 1,   Remission↑, 1,   TumVol↓, 1,  
Total Targets: 81

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↝, 1,  
Total Targets: 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:25  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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