TumCMig Cancer Research Results

TumCMig, Tumor cell migration: Click to Expand ⟱
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Tumor cell migration is a critical process in cancer progression and metastasis, which is the spread of cancer cells from the primary tumor to distant sites in the body.
Var, Various Cancer: Click to Expand ⟱
Cyclooxygenase (COX)-2 overexpression has been noted in various cancers. PI3Ks/AKT pathways are over-activated in several types of cancers.
EGFR altered activity has been noted in various pathological conditions. However, its regulation is an important step in the inhibition of cancer. In this regard, EGCG shows a pivotal role in the inhibition of EGFR activity.
Activating protein-1 transcription factor has been associated with pathogenesis including cancer.
Activation of the sonic hedgehog (Shh) pathway is required for the growth of numerous tissues and organs and recent evidence indicates that this pathway is often recruited to stimulate growth of cancer stem cells (CSCs) and to orchestrate the reprogramming of cancer cells via epithelial mesenchymal transition (EMT). Increased expression of Nanog has been associated with the aggressive nature of certain cancers, highlighting its role in promoting cancer stem cell characteristics.
The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression of a variety of tumors.
The process of cell apoptosis is often accompanied by the destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Human malignancies frequently exhibit mutations in the TGF-β pathway, and overactivation of this system is linked to tumor growth by promoting angiogenesis and inhibiting the innate and adaptive antitumor immune responses50.
Several studies have demonstrated that high cyclin D1 expression was observed in cancers including breast, lung, prostate, lymph node and colorectal cancers [23–25].
The oncogene c-myc, which is frequently over-expressed in cancer cells, is involved in the transactivation of most of the glycolytic enzymes including lactate dehydrogenase A (LDHA) and the glucose transporter GLUT1 [51,52]. Thus, c-myc activation is a likely candidate to promote the enhanced glucose uptake and lactate release in the proliferating cancer cell.
Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin’s overexpression in cancer correlates well with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure.
Heat shock proteins (HSPs) are normally induced under environmental stress to serve as chaperones for maintenance of correct protein folding but they are often overexpressed in many cancers, including breast cancer.
Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 and NQO1-targeted drug delivery have been active areas of research.
Since increased Nrf2 gene expression is one of the main mechanisms of cancer cells in resisting chemotherapeutic drugs and survival in oxidative conditions; finding compounds with the ability to suppress Nrf2 gene expression with minimum side effects can be considered an important strategy for increasing the sensitivity of cancer cells to chemotherapy.
Overexpression of c-met stimulates proliferation, migration and invasion in various types of cancer including prostate cancer.
Overexpression of TGFα and EGFR by many carcinomas correlates with the development of cancer metastasis, resistance to chemotherapy and poor prognosis.
More than 50% of human cancers have a mutated nonfunctional p53.


Scientific Papers found: Click to Expand⟱
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
5136- ART/DHA,    Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis
- in-vitro, Var, NA
angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
5415- ASA,    The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review
- Review, Var, NA
TumMeta↓, COX1↓, TXA2↓, AntiAg↑, EMT↓, TumCMig↓, TumCI↓, AMPK↑, cMyc↓, PGE2↓, Dose↑, RadioS↑, PD-L1↓, E-cadherin↑, EMT↓, Slug↓, Vim↓, Twist↓, MMP2↓, MMP9↓, other↑,
4807- ASTX,    An overview of the anticancer activity of astaxanthin and the associated cellular and molecular mechanisms
- Review, Var, NA
*antiOx↑, *neuroP↑, AntiCan↑, TumCG↓, TumCD↑, TumCMig↓, ChemoSen↑, chemoP↑, *BioAv↓, TumCP↓, TumCCA↑, Apoptosis↑, BioAv↑,
4980- ATV,    A review of effects of atorvastatin in cancer therapy
- Review, Var, NA
HMG-CoA↓, TumCP↓, TumCMig↓,
5362- AV,    Anti-cancer effects of aloe-emodin: a systematic review
- Review, Var, NA
AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, eff↑, P-gp↓, BioAv↑, selectivity↑,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
2615- Ba,    The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
- Review, Var, NA
*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,
5536- BBM,    Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers
- Review, Var, NA
JAK↝, STAT3↓, p‑CaMKII ↓, TGF-β↑, Smad1↑, ChemoSen↑, RadioS↑, TumCI↓, TumCMig↓, ROS↑, NRF2↓, SOD2↓, GPx1↓, HO-1↓,
5515- BEV,    Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro.
- Review, Var, NA
VEGF↓, TumCP↓, tumCV↓, TumCMig↓,
5715- BF,    Bufalin for an innovative therapeutic approach against cancer
- Review, Var, NA
selectivity↑, TumCP↓, TumCCA↓, TumCD↑, Apoptosis↑, TumAuto↑, TumMeta↓, TumCMig↓, TumCI↓, angioG↓, CSCs↓,
5477- BM,    The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis.
- in-vitro, Var, NA
AQPs↓, tumCV↓, Apoptosis↑, TumCMig↓,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
5849- CAP,    The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
- Review, Var, NA
TRPV1↑, Ca+2↑, TumCD↑, TumCCA↑, Apoptosis↑, P53↑, Fas↑, PI3K↑, AR↑, STAT3↓, ROS↑, MMP↓, ATP↓, CHOP↑, TumCMig↓, Twist↓, Snail↓, MMP2↓, MMP9↓, E-cadherin↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5890- CAR,    Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways
- Review, Var, NA
selectivity↑, TumCG↓, *Inflam↓, *antiOx↑, TumCCA↑, TumCMig↓, TumCI↓, angioG↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
6014- CGA,    Exploring the Pharmacological Potential of Chlorogenic acid as an Anti-Cancer Agent and a Call for Advance Research
- Review, Var, NA
AntiCan↑, *hepatoP↑, *Bacteria↓, *antiOx↓, *AntiDiabetic↑, Apoptosis↓, TumCG↓, angioG↓, TumCI↓, TumCMig↓, ROS↝, Inflam↝,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
4709- CUR,    Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
- Review, Var, NA
miR-21↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-99↑, JAK↓, STAT↓, cycD1/CCND1↓, P21↑, ChemoSen↑, miR-192-5p↑, cMyc↓, Wnt↓, β-catenin/ZEB1↓, miR-130a↓,
5071- dietSTF,    Unraveling the impact of intermittent fasting in cancer prevention, mitigation, and treatment: A narrative review
- Review, Var, NA - Review, AD, NA
Risk↓, TumCMig↓, IGF-1↓, TumAuto↑, Inflam↓, ChemoSen↑, Apoptosis↑, chemoP↑, *glucose↓, *AntiDiabetic↑, *cardioP↑, *LDL↓, *BP↓, *neuroP↑, *cognitive↑, *memory↑, *OS↑, *QoL↑, Imm↑, TumCG↓, ChemoSideEff↓, QoL↑,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2↓, lipid-P↓, GSH↑, NRF2↑,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
1663- PBG,    Propolis and Their Active Constituents for Chronic Diseases
- Review, Var, NA
NF-kB↓, Casp↓, Fas↓, DNAdam↑, Casp3↑, P53↝, MMP↝, ROS↑, mtDam↑, Dose?, angioG↓, TumCP↓, TumCMig↓, BAX↑, selectivity↑, MMP↓, LDH↓, IL6↓, IL1β↓, TNF-α↓,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3089- RES,    The Role of Resveratrol in Cancer Therapy
- Review, Var, NA
angioG↓, VEGF↓, EGFR↓, FGF↑, TumCMig↓, TumCI↓, TIMP1↑, MMP2↓, MMP9↓, NF-kB↓, Hif1a↓, PI3K↓, Akt↓, MAPK↓, EMT↓, AR↓,
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
3306- SIL,  Rad,    Radioprotective and radiosensitizing properties of silymarin/silibinin in response to ionizing radiation
- Review, Var, NA
radioP↑, RadioS↑, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, DNAdam↓, ROS↑, *ROS↓, *Inflam↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
2355- SK,    Pharmacological properties and derivatives of shikonin-A review in recent years
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, TumAuto↑, Necroptosis↑, ROS↑, TrxR1↓, PKM2↓, RIP1↓, RIP3↓, Src↓, FAK↓, PI3K↓, Akt↓, mTOR↓, GRP58↓, MMPs↓, ATF2↓, cl‑PARP↑, Casp3↑, p‑p38↑, p‑JNK↑, p‑ERK↓,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,

Showing Research Papers: 1 to 50 of 52
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 52

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP2E1↑, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GPx↑, 1,   GPx1↓, 1,   GSH↓, 8,   GSH↑, 1,   H2O2↓, 1,   HO-1↓, 2,   HO-1↑, 2,   lipid-P↓, 2,   lipid-P↑, 3,   NRF2↓, 1,   NRF2↑, 4,   ROS↓, 6,   ROS↑, 30,   ROS↝, 2,   mt-ROS↑, 1,   SIRT3↑, 1,   SOD↓, 1,   SOD2↓, 1,   Trx↓, 1,   TrxR1↓, 2,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 4,   CDC25↓, 1,   EGF↓, 1,   FGFR1↓, 2,   mitResp↑, 1,   MMP↓, 13,   MMP↝, 1,   MPT↑, 1,   mtDam↑, 2,   OCR↓, 1,   OCR↑, 1,   c-Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ALAT↓, 1,   AMPK↑, 4,   ATG7↑, 1,   cMyc↓, 11,   CYP3A4↓, 1,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 4,   HK2↓, 3,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 2,   PPARγ↑, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 20,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 26,   ATF2↓, 1,   BAX↓, 1,   BAX↑, 9,   Bax:Bcl2↑, 3,   Bcl-2↓, 11,   Bcl-xL↓, 1,   Casp↓, 1,   Casp↑, 2,   Casp12↑, 1,   Casp3↑, 11,   cl‑Casp3↑, 4,   Casp7↑, 2,   cl‑Casp7↑, 1,   Casp8↑, 5,   cl‑Casp8↑, 3,   Casp9↑, 8,   cl‑Casp9↑, 4,   cFLIP↓, 2,   CK2↓, 1,   Cyt‑c↑, 7,   DR4↑, 1,   DR5↑, 3,   FADD↑, 1,   Fas↓, 2,   Fas↑, 6,   FasL↓, 1,   Ferroptosis↑, 1,   GRP58↓, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   IAP2↓, 1,   iNOS↓, 2,   JNK↓, 1,   JNK↑, 4,   p‑JNK↑, 1,   MAPK↓, 3,   MAPK↑, 2,   p‑MAPK↑, 1,   Mcl-1↓, 2,   Mcl-1↑, 1,   Myc↑, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p27↓, 1,   p27↑, 3,   p38↑, 4,   p‑p38↑, 2,   PUMA↑, 2,   RIP1↓, 1,   survivin↓, 8,   Telomerase↓, 1,   TRPV1↑, 1,   TumCD↑, 4,  

Kinase & Signal Transduction ⓘ

p‑CaMKII ↓, 1,   EF-1α↓, 1,   HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 2,   cJun↑, 1,   H3↓, 1,   H3↑, 1,   H4↑, 1,   HATs↑, 1,   miR-192-5p↑, 1,   miR-21↓, 1,   other↑, 1,   other↝, 1,   p‑pRB↓, 1,   tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   cl‑CHOP↑, 1,   eIF2α↑, 2,   ER Stress↑, 7,   GRP78/BiP↑, 4,   IRE1↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↑, 7,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   DNAdam↓, 1,   DNAdam↑, 10,   P53↑, 13,   P53↝, 1,   PARP↑, 2,   cl‑PARP↑, 7,   PCNA↓, 7,   γH2AX↑, 1,   γH2AX↝, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 8,   CDK2↑, 1,   CDK4↓, 8,   CDK4↑, 2,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 10,   cycE/CCNE↓, 3,   P21?, 1,   P21↑, 8,   RB1↑, 2,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↓, 3,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 2,   cFos↓, 1,   p‑cMET↑, 1,   CSCs↓, 6,   Diff↑, 1,   EMT↓, 14,   ERK↓, 8,   ERK↑, 2,   p‑ERK↓, 1,   FGF↓, 1,   FGF↑, 1,   FGFR2↓, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO3↓, 1,   GSK‐3β↓, 3,   HDAC↓, 4,   IGF-1↓, 2,   miR-99↑, 1,   mTOR↓, 8,   mTOR↑, 1,   p‑mTOR↓, 3,   mTORC1↓, 2,   mTORC2↓, 2,   Nanog↓, 1,   Nestin↓, 2,   NOTCH1↓, 3,   NOTCH3↓, 1,   OCT4↓, 1,   P70S6K↓, 1,   PI3K↓, 13,   PI3K↑, 1,   PTEN↑, 4,   RAS↓, 1,   RAS↑, 1,   Shh↓, 1,   SOX2↓, 1,   Src↓, 1,   STAT↓, 1,   STAT3↓, 7,   p‑STAT3↓, 3,   p‑STAT3↑, 1,   TCF-4↓, 1,   TumCG↓, 8,   TumCG↑, 1,   tyrosinase↓, 1,   Wnt↓, 5,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Ca+2↑, 5,   i-Ca+2↑, 1,   CDKN1C↑, 1,   CLDN1↓, 1,   CLDN2↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 7,   FAK↓, 2,   p‑FAK↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   Ki-67↓, 2,   MET↓, 1,   miR-130a↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 17,   MMP3↓, 1,   MMP7↓, 5,   MMP9↓, 17,   MMPs↓, 6,   N-cadherin↓, 2,   PDGF↓, 1,   PKCδ↓, 2,   Rho↑, 1,   RIP3↓, 1,   ROCK1↑, 1,   Slug↓, 1,   Smad1↑, 1,   Snail↓, 1,   SOX4↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↑, 3,   TIMP2↑, 2,   TIMP3↑, 1,   TSP-1↑, 1,   TumCA↓, 2,   TumCI↓, 27,   TumCMig↓, 51,   TumCP↓, 27,   TumMeta↓, 9,   Twist↓, 6,   uPA↓, 3,   Vim↓, 4,   Zeb1↓, 3,   ZEB2↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 18,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 8,   HIF-1↓, 2,   Hif1a↓, 9,   LOX1↓, 1,   NO↓, 1,   TXA2↓, 1,   VEGF↓, 15,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

AQPs↓, 1,   GLUT1↓, 1,   P-gp↓, 4,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 11,   CXCR4↓, 4,   IFN-γ↓, 1,   IKKα↓, 1,   IL1↓, 2,   IL1β↓, 3,   IL2↓, 1,   IL4↓, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 8,   Inflam↝, 1,   JAK↓, 1,   JAK↝, 1,   JAK2↓, 2,   NF-kB↓, 23,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p65↓, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PGE2↓, 6,   PSA↓, 3,   TLR4↓, 1,   TNF-α↓, 6,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,   AR↑, 1,   CDK6↓, 2,   CDK6↑, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 1,   BioEnh?, 1,   ChemoSen↑, 21,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 6,   Dose∅, 1,   eff↓, 1,   eff↑, 21,   eff↝, 2,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 2,   P450↓, 1,   RadioS↑, 10,   selectivity↑, 15,  

Clinical Biomarkers ⓘ

AFP↓, 1,   ALAT↓, 1,   AR↓, 3,   AR↑, 1,   AST↓, 1,   BMPs↑, 2,   EGFR↓, 8,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   Ki-67↓, 2,   LDH↓, 1,   Myc↑, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PSA↓, 3,  

Functional Outcomes ⓘ

AntiCan↑, 10,   AntiTum↑, 2,   chemoP↑, 7,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   NDRG1↑, 1,   neuroP↑, 2,   OS↑, 3,   QoL↑, 1,   radioP↑, 1,   Risk↓, 4,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 3,  
Total Targets: 381

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 2,   antiOx↑, 15,   Catalase↑, 5,   GPx↑, 3,   GPx1↑, 1,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 3,   HDL↑, 1,   HO-1↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 4,   MDA↓, 1,   MPO↓, 3,   NRF2↑, 5,   ROS↓, 16,   ROS↑, 1,   SAM-e↑, 1,   SIRT3↑, 1,   SOD↑, 5,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↝, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 3,   glucose↓, 1,   H2S↑, 1,   LDH↓, 4,   LDL↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   PPARγ↑, 2,  

Cell Death ⓘ

Akt↓, 1,   Casp3↓, 2,   Fas↓, 1,   iNOS↓, 5,   MAPK↓, 1,   Telomerase↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   PI3K↓, 1,   PTEN↑, 1,  

Migration ⓘ

AntiAg↑, 2,   Ca+2↝, 1,   p‑Rac1↓, 1,   Rho↓, 1,   serineP↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 3,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 7,   IFN-γ↓, 1,   IKKα↑, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL6↓, 4,   Imm↑, 1,   Inflam↓, 12,   MyD88↓, 1,   NF-kB↓, 6,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 5,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   AChE↑, 1,   BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   BACE↓, 1,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   BioAv↑, 3,   BioAv↝, 1,   Dose↑, 1,   Dose↝, 4,   eff↑, 3,   Half-Life↝, 2,   P450↓, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 3,   ALP↓, 2,   AST↓, 3,   BMD↑, 1,   BMPs↑, 1,   BP↓, 2,   Calcium↑, 1,   creat↓, 1,   GutMicro↑, 1,   hs-CRP↓, 1,   IL6↓, 4,   LDH↓, 4,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiDiabetic↑, 2,   cardioP↑, 7,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 3,   hepatoP↑, 5,   memory↑, 4,   neuroP↑, 13,   OS↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 2,   toxicity↝, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 2,   IRF3↓, 1,  
Total Targets: 124

Scientific Paper Hit Count for: TumCMig, Tumor cell migration
3 Baicalein
3 Propolis -bee glue
3 Fisetin
3 Honokiol
3 Silymarin (Milk Thistle) silibinin
2 Artemisinin
2 Carvacrol
2 Lycopene
2 Resveratrol
2 Thymoquinone
1 Astragalus
1 Allicin (mainly Garlic)
1 Aspirin -acetylsalicylic acid
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 Bevacizumab (brand Avastin)
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Boron
1 Boswellia (frankincense)
1 Caffeic acid
1 Capsaicin
1 Celecoxib
1 Chlorogenic acid
1 Chrysin
1 Curcumin
1 diet Short Term Fasting
1 Disulfiram
1 Copper and Cu NanoParticles
1 Ferulic acid
1 Magnolol
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Radiotherapy/Radiation
1 Shikonin
1 Aflavin-3,3′-digallate
1 Thymol-Thymus vulgaris
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:26  Cells:%  prod#:%  Target#:326  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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