chemoPv Cancer Research Results

chemoPv, ChemoPreventive: Click to Expand ⟱
Source:
Type:
Chemopreventive: An agent that lowers the probability of cancer development or delays progression from premalignant states.
Mechanisms
-Reduce DNA damage / mutagenesis
-Enhance detoxification or repair
-Modulate hormones or inflammation
-Promote differentiation or apoptosis of abnormal cells


Var, Various Cancer: Click to Expand ⟱
Cyclooxygenase (COX)-2 overexpression has been noted in various cancers. PI3Ks/AKT pathways are over-activated in several types of cancers.
EGFR altered activity has been noted in various pathological conditions. However, its regulation is an important step in the inhibition of cancer. In this regard, EGCG shows a pivotal role in the inhibition of EGFR activity.
Activating protein-1 transcription factor has been associated with pathogenesis including cancer.
Activation of the sonic hedgehog (Shh) pathway is required for the growth of numerous tissues and organs and recent evidence indicates that this pathway is often recruited to stimulate growth of cancer stem cells (CSCs) and to orchestrate the reprogramming of cancer cells via epithelial mesenchymal transition (EMT). Increased expression of Nanog has been associated with the aggressive nature of certain cancers, highlighting its role in promoting cancer stem cell characteristics.
The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression of a variety of tumors.
The process of cell apoptosis is often accompanied by the destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Human malignancies frequently exhibit mutations in the TGF-β pathway, and overactivation of this system is linked to tumor growth by promoting angiogenesis and inhibiting the innate and adaptive antitumor immune responses50.
Several studies have demonstrated that high cyclin D1 expression was observed in cancers including breast, lung, prostate, lymph node and colorectal cancers [23–25].
The oncogene c-myc, which is frequently over-expressed in cancer cells, is involved in the transactivation of most of the glycolytic enzymes including lactate dehydrogenase A (LDHA) and the glucose transporter GLUT1 [51,52]. Thus, c-myc activation is a likely candidate to promote the enhanced glucose uptake and lactate release in the proliferating cancer cell.
Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin’s overexpression in cancer correlates well with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure.
Heat shock proteins (HSPs) are normally induced under environmental stress to serve as chaperones for maintenance of correct protein folding but they are often overexpressed in many cancers, including breast cancer.
Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 and NQO1-targeted drug delivery have been active areas of research.
Since increased Nrf2 gene expression is one of the main mechanisms of cancer cells in resisting chemotherapeutic drugs and survival in oxidative conditions; finding compounds with the ability to suppress Nrf2 gene expression with minimum side effects can be considered an important strategy for increasing the sensitivity of cancer cells to chemotherapy.
Overexpression of c-met stimulates proliferation, migration and invasion in various types of cancer including prostate cancer.
Overexpression of TGFα and EGFR by many carcinomas correlates with the development of cancer metastasis, resistance to chemotherapy and poor prognosis.
More than 50% of human cancers have a mutated nonfunctional p53.


Scientific Papers found: Click to Expand⟱
5168- AL,    Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells
- in-vitro, Var, NA
TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2596- Api,  LT,    Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment
- Review, Var, NA
NRF2↓, chemoPv↑, ChemoSen↑,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
4814- ASTX,    Chemopreventive and therapeutic efficacy of astaxanthin against cancer: A comprehensive review
- Review, Var, NA
Apoptosis↑, EMT↓, AntiCan↑, *cardioP↑, *neuroP↑, TumCG↓, *antiOx↑, *Bacteria↓, *Imm↑, *hepatoP↑, *AntiDiabetic↑, ROS↓, *chemoPv↑,
5427- ASTX,    Astaxanthin and Cancer Chemoprevention
- Review, Var, NA
chemoP↑, AntiCan↑, chemoPv↑, Risk↓, lipid-P↓, Pain↓, BioAv↑, Dose↝,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, eff↑, chemoPv↑, BioAv↓,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE↓, *BioAv↑, P-gp⇅,
5632- BCA,    Pharmacokinetics and bioavailability of the isoflavone biochanin A in rats
- in-vivo, Var, NA
chemoPv↑, *BioAv↓,
5582- BetA,    Targeting mitochondrial apoptosis by betulinic acid in human cancers
- Review, Var, NA
Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
2759- BetA,    Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies
- Review, Var, NA
chemoPv↑, ChemoSen↑, *Inflam↓, *NRF2↑, *NF-kB↓, *COX2↓, ROS↑, MMP↓, Sp1/3/4↓, VEGF↓,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
5745- Buty,    Microbial Oncotarget: Bacterial-Produced Butyrate, Chemoprevention and Warburg Effect
- Review, Var, NA
selectivity↑, HDAC↓, TumCP↓, Apoptosis↑, Warburg↓, chemoPv↑,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, eff↑, ChemoSen↑, *memory↑, *ROS↓,
5833- CAP,    Capsaicin: From Plants to a Cancer-Suppressing Agent
- Review, Var, NA
chemoPv↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Ca+2↑, JNK↑, Casp3↑, NADH↓, CDK2↓, CDK4↓, CDK6↓, P53↑,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5772- CAPE,    The Pluripotent Activities of Caffeic Acid Phenethyl Ester
- Review, Var, NA
*Bacteria↓, *AntiCan↑, *Imm↑, *Wound Healing↑, *NF-kB↓, *5LO↓, *AntiDiabetic↑, ChemoSen↑, selectivity↑, chemoPv↑,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
6016- CGA,    Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
antiOx↑, *Bacteria↓, AntiCan↑, *Inflam↓, *cardioP↑, *AntiDiabetic↑, *GutMicro↑, *eff↑, *eff↑, *ROS↓, *IronCh↑, *neuroP↑, *AChE↓, *BChE↓, *chemoPv↑, *BioAv⇅,
6072- CHL,    Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
- in-vivo, Var, NA
AntiCan↑, AntiTum↑, chemoPv↑,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
4654- CUR,    Stem Cell Therapy: Curcumin Does the Trick
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, chemoPv↑, *AntiAge↑, *neuroP↑, *Wound Healing↑,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, eff↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
2438- Gra,    Emerging therapeutic potential of graviola and its constituents in cancers
- Review, Var, NA
Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
4970- Nimb,    Insights into Nimbolide molecular crosstalk and its anticancer properties
- Review, Var, NA
chemoPv↑, Apoptosis↑, TumCP↓, TumCD↑, TumMeta↓, angioG↓,
4628- OLE,    Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases
- in-vitro, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumCI↓, TumMeta↓,
4964- PEITC,    Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical
- in-vitro, Var, NA
GSH↓, GSTA1↓, chemoPv↑,
3071- RES,    Resveratrol and Its Anticancer Effects
- Review, Var, NA
chemoPv↑, SIRT1↑, Hif1a↓, VEGF↓, STAT3↓, NF-kB↓, COX2↓, PI3K↓, mTOR↓, NRF2↑, NLRP3↓, H2O2↑, ROS↑, P53↑, PUMA↑, BAX↑,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
4663- RES,    Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models
- Review, Var, NA
*antiOx↑, *Inflam↓, *chemoPv↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, PI3K↓, Akt↓, mTOR↓, GSK‐3β↝, Snail↓, HH↓, p‑GSK‐3β↓, N-cadherin↓, EMT↓, CD133↓, CD44↓, ALDH1A1↓, OCT4↓, SOX4↓, Shh↓, Smo↓, Gli1↓, GLI2↓,
4457- SeNPs,    Selenium nanoparticles: a review on synthesis and biomedical applications
- Review, Var, NA - NA, Diabetic, NA
*BioAv↑, *toxicity↓, *eff↑, chemoPv↑, *Inflam↓, antiOx↑, *selenoP↑, *ROS↓, *Dose↝, AntiCan↑, *Bacteria↓, eff↑, DNAdam↑, selectivity↑, *eff↑,
2555- SFN,    Chemopreventive functions of sulforaphane: A potent inducer of antioxidant enzymes and apoptosis
- Review, Var, NA
chemoPv↑, HDAC↓, TumCCA↑, Apoptosis↑, Mets↑, *NRF2↑, ROS⇅,
2556- SFN,    The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review
- Review, Var, NA
chemoPv↑, HDAC↓, Hif1a↓, angioG↓, CYP1A1↓, eff↑, BioAv↑,
2552- SFN,  Chemo,    Chemopreventive activity of sulforaphane
- Review, Var, NA
chemoPv↑, TumCG↓, *ROS↓, *Inflam↓, *Dose↝, *NRF2↑, *HO-1↑, *NQO1↑, NF-kB↓, ROS↑,
2554- SFN,    Sulforaphane (SFN): An Isothiocyanate in a Cancer Chemoprevention Paradigm
- Review, Var, NA
Dose↝, chemoPv↑, *NQO1↑, *GSTA1↑, HDAC↓, NF-kB↓,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27↑, ROS↑, DNAdam↑, MUC4↓,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2↑, XIAP↓, TNF-α↓, COX2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, BioAv↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,

Showing Research Papers: 1 to 50 of 52
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 52

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↓, 1,   Catalase↑, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   Fenton↑, 1,   GPx↓, 1,   GSH↓, 2,   GSTA1↓, 1,   H2O2↑, 1,   HO-1↑, 1,   lipid-P?, 1,   lipid-P↓, 1,   lipid-P↑, 1,   Mets↑, 1,   NADH↓, 1,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 2,   OXPHOS↓, 1,   Prx↓, 1,   ROS↓, 3,   ROS↑, 18,   ROS⇅, 2,   mt-ROS↑, 1,   SOD↓, 2,   SOD2↓, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mitResp↓, 1,   mitResp↑, 1,   MMP↓, 8,   MMP↑, 1,   MPT↑, 1,   mtDam↑, 2,   OCR↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AMPK↑, 5,   cMyc↓, 1,   FASN↓, 2,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 1,   LDHA↓, 1,   NADPH↑, 2,   PPARα↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 12,   Akt↑, 1,   APAF1↑, 1,   Apoptosis↑, 18,   BAX↑, 1,   Bax:Bcl2↑, 4,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp↑, 2,   Casp12↑, 1,   Casp3↑, 10,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   cFLIP↓, 1,   CK2↓, 3,   Cyt‑c↑, 9,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 2,   Fap1↓, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   IAP2↑, 1,   cl‑IAP2↑, 1,   iNOS↓, 1,   JNK↑, 5,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 2,   p27↑, 2,   p38↑, 2,   PUMA↑, 1,   survivin↓, 2,   Telomerase↓, 3,   TRPV1↑, 2,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,   Sp1/3/4↓, 4,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   miR-21↓, 1,   other↓, 2,   p‑pRB↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 3,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   HSPs↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   LC3II↑, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 4,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↓, 1,   P53↑, 8,   cl‑PARP↑, 6,   PCNA↓, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 5,   CDK4↓, 6,   Cyc↓, 1,   cycD1/CCND1↓, 6,   CycD3↓, 1,   cycE/CCNE↓, 2,   P21↑, 5,   p‑RB1↓, 1,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   AR-V7?, 1,   CD133↓, 1,   CD44↓, 1,   CSCs↓, 5,   EMT↓, 7,   ERK↓, 1,   p‑ERK↓, 1,   FOXO3↑, 3,   Gli↓, 1,   Gli1↓, 2,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   HDAC↓, 6,   HDAC1↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   HH↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   Let-7↑, 1,   miR-34a↑, 1,   mTOR↓, 9,   NOTCH↓, 2,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 10,   PTCH1↓, 1,   PTEN↑, 1,   RAS↓, 1,   SCF↓, 2,   Shh↓, 1,   Smo↓, 1,   STAT3↓, 7,   p‑STAT3↓, 2,   TOP1↓, 2,   TOP2↑, 1,   TumCG↓, 5,   Wnt↓, 5,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↑, 7,   i-Ca+2?, 1,   cal2↑, 1,   E-cadherin↑, 3,   FAK↓, 2,   GLI2↓, 2,   ITGB4↓, 1,   miR-200b↑, 1,   miR-29b↓, 1,   MMP1↓, 1,   MMP2↓, 6,   MMP9↓, 8,   MMPs↓, 2,   MUC4↓, 3,   N-cadherin↓, 3,   PDGF↓, 3,   Rac1↓, 1,   Snail↓, 2,   SOX4↓, 1,   TumCI↓, 7,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 6,   TumMeta↑, 1,   Twist↓, 2,   uPA↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature ⓘ

angioG↓, 13,   EGFR↓, 3,   HIF-1↓, 1,   Hif1a↓, 9,   Hif1a↑, 1,   NO↝, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 11,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 1,   GLUT1↓, 3,   GLUT4↓, 1,   P-gp⇅, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 9,   CXCR4↓, 1,   IKKα↓, 2,   IL1α↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 4,   IκB↓, 1,   JAK1↓, 1,   JAK2↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 14,   NF-kB↑, 2,   p‑NF-kB↓, 1,   p‑p65↓, 1,   PGE2↓, 3,   PSA↓, 3,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,   CDK6↓, 4,   CYP19?, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 6,   BioAv↑, 6,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 17,   ChemoSen∅, 1,   Dose↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 17,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 1,   RadioS↑, 6,   selectivity↑, 10,  

Clinical Biomarkers ⓘ

AR↓, 3,   ascitic↓, 1,   EGFR↓, 3,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 2,   LDH↓, 1,   PSA↓, 3,  

Functional Outcomes ⓘ

AntiCan↑, 11,   AntiTum↑, 1,   chemoP↑, 2,   chemoPv↑, 41,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 3,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 3,   toxicity↓, 2,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 268

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 8,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   GSTA1↑, 1,   GSTs↑, 1,   HO-1↑, 1,   MDA↓, 1,   NQO1↑, 2,   NRF2↑, 3,   ROS↓, 12,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↝, 1,   Insulin↑, 1,   MMP∅, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 1,   PPARα↑, 1,   p‑PPARγ↓, 1,  

Cell Death ⓘ

BAX↓, 1,   Casp3∅, 1,   Cyt‑c∅, 1,   iNOS↓, 1,   MAPK↓, 1,   MAPK↑, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

PCNA↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,   Ca+2↓, 1,   Ca+2↝, 2,   MMP9↓, 1,   PKCδ↓, 1,   serineP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 2,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 17,   NF-kB↓, 5,   PGE2↓, 1,   TNF-α↓, 4,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv⇅, 1,   BioAv↝, 2,   Dose↑, 3,   Dose↝, 3,   eff↑, 6,   Half-Life↝, 3,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BMPs↑, 1,   Calcium↑, 1,   GutMicro↑, 1,   hs-CRP↓, 1,   IL6↓, 2,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 1,   AntiDiabetic↑, 4,   cardioP↑, 3,   cardioP⇅, 1,   chemoP↑, 1,   chemoPv↑, 10,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 3,   neuroP↑, 6,   Obesity↓, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 2,   Wound Healing↑, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 4,  
Total Targets: 90

Scientific Paper Hit Count for: chemoPv, ChemoPreventive
4 Apigenin (mainly Parsley)
4 Capsaicin
4 Sulforaphane (mainly Broccoli)
3 Chemotherapy
3 Betulinic acid
3 Chrysin
3 Resveratrol
2 Astaxanthin
2 Biochanin A
2 Thymoquinone
1 Allicin (mainly Garlic)
1 Luteolin
1 Ashwagandha(Withaferin A)
1 Berberine
1 Boron
1 Boswellia (frankincense)
1 Butyrate
1 Caffeic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celecoxib
1 Celastrol
1 Chlorogenic acid
1 Chlorophyllin
1 Chocolate
1 Coenzyme Q10
1 Curcumin
1 Fisetin
1 Genistein (soy isoflavone)
1 Graviola
1 Honokiol
1 Nimbolide
1 Oleuropein
1 Phenethyl isothiocyanate
1 Selenium NanoParticles
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:26  Cells:%  prod#:%  Target#:1417  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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