BAX Cancer Research Results

BAX, Apoptosis regulator BAX: Click to Expand ⟱
Source:
Type: Proapototic protein
BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.
Var, Various Cancer: Click to Expand ⟱
Cyclooxygenase (COX)-2 overexpression has been noted in various cancers. PI3Ks/AKT pathways are over-activated in several types of cancers.
EGFR altered activity has been noted in various pathological conditions. However, its regulation is an important step in the inhibition of cancer. In this regard, EGCG shows a pivotal role in the inhibition of EGFR activity.
Activating protein-1 transcription factor has been associated with pathogenesis including cancer.
Activation of the sonic hedgehog (Shh) pathway is required for the growth of numerous tissues and organs and recent evidence indicates that this pathway is often recruited to stimulate growth of cancer stem cells (CSCs) and to orchestrate the reprogramming of cancer cells via epithelial mesenchymal transition (EMT). Increased expression of Nanog has been associated with the aggressive nature of certain cancers, highlighting its role in promoting cancer stem cell characteristics.
The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression of a variety of tumors.
The process of cell apoptosis is often accompanied by the destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Human malignancies frequently exhibit mutations in the TGF-β pathway, and overactivation of this system is linked to tumor growth by promoting angiogenesis and inhibiting the innate and adaptive antitumor immune responses50.
Several studies have demonstrated that high cyclin D1 expression was observed in cancers including breast, lung, prostate, lymph node and colorectal cancers [23–25].
The oncogene c-myc, which is frequently over-expressed in cancer cells, is involved in the transactivation of most of the glycolytic enzymes including lactate dehydrogenase A (LDHA) and the glucose transporter GLUT1 [51,52]. Thus, c-myc activation is a likely candidate to promote the enhanced glucose uptake and lactate release in the proliferating cancer cell.
Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin’s overexpression in cancer correlates well with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure.
Heat shock proteins (HSPs) are normally induced under environmental stress to serve as chaperones for maintenance of correct protein folding but they are often overexpressed in many cancers, including breast cancer.
Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 and NQO1-targeted drug delivery have been active areas of research.
Since increased Nrf2 gene expression is one of the main mechanisms of cancer cells in resisting chemotherapeutic drugs and survival in oxidative conditions; finding compounds with the ability to suppress Nrf2 gene expression with minimum side effects can be considered an important strategy for increasing the sensitivity of cancer cells to chemotherapy.
Overexpression of c-met stimulates proliferation, migration and invasion in various types of cancer including prostate cancer.
Overexpression of TGFα and EGFR by many carcinomas correlates with the development of cancer metastasis, resistance to chemotherapy and poor prognosis.
More than 50% of human cancers have a mutated nonfunctional p53.


Scientific Papers found: Click to Expand⟱
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
245- AL,    Allicin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,
254- AL,    Allicin and Cancer Hallmarks
- Review, Var, NA
NRF2⇅, BAX↑, Bcl-2↓, Fas↑, MMP↓, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Casp12↑, GSH↓, TumCCA↑, ROS↑, antiOx↓,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB/CCNB1↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- NA, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, eff↑, OS↑, Remission↑,
5568- B-Gluc,  immuno,    Beta-glucans in oncology: revolutionizing treatment with immune power & tumor targeting
- Review, Var, NA
TNF-α↓, IL6↓, NF-kB↓, PD-L1↓, Imm↑, BAX↑, Bcl-2↓, TumCCA↑, angioG↓, VEGF↓, MMPs↓, OS↑, chemoP↑, eff↑, BioAv↑,
5502- Ba,    An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways
- Review, Var, NA
*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2743- BetA,    Betulinic acid and the pharmacological effects of tumor suppression
- Review, Var, NA
ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, TumCCA↑, Sp1/3/4↓, STAT3↓, NF-kB↓, EMT↓, TOP1↓, MAPK↑, p38↑, JNK↑, Casp↑, Bcl-2↓, BAX↑, VEGF↓, LAMs↓,
1285- BetA,    Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells
- in-vitro, Var, NA
Apoptosis↑, Bcl-2↓, cycD1/CCND1↓, BAX↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2↓, ROS↑,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, BioAv↝, BioAv↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, eff↑, COX2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
1324- EMD,    Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin
- Review, Var, NA
*toxicity↑, *BioAv↓, Akt↓, ERK↓, ROS↑, MMP↓, Bcl-2↓, BAX↑, TumCCA↑,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, eff↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP↑, eff↑, ChemoSen↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2↓, IAP2↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP↑, ROS↑, cMyc↓, cardioP↑,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
5113- JG,    Juglone in Oxidative Stress and Cell Signaling
- Review, Var, NA - Review, AD, NA
ROS↑, Pin1↓, antiOx⇅, *ROS↓, SMAD2↓, GSH↓, lipid-P↑, TumCCA↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Ca+2↑, Cyt‑c↑, AntiFungal↑, Bacteria↓, Akt↓,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, eff↑, BAX↑, Fas↑, Pin1↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1↓, Hif1a↓, LC3II↑, Beclin-1↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,
1715- Lyco,    Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence
- Review, Var, NA
antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, eff↑,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↓, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,

Showing Research Papers: 1 to 50 of 85
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 85

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 3,   antiOx↑, 1,   antiOx⇅, 2,   ARE↑, 1,   Catalase↓, 3,   Catalase↑, 1,   Copper↑, 1,   CYP1A1↓, 1,   Ferroptosis↑, 2,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 4,   GSH↓, 8,   GSTs↓, 1,   GSTs↑, 2,   HO-1↓, 3,   HO-1↑, 2,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 3,   lipid-P↑, 1,   MAD↓, 1,   MDA↓, 1,   MDA↑, 1,   NOX4↑, 1,   NRF2↓, 5,   NRF2↑, 4,   NRF2⇅, 1,   p‑NRF2↓, 1,   PYCR1↓, 1,   ROS↓, 4,   ROS↑, 38,   ROS⇅, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SIRT3↓, 1,   SOD↓, 4,   SOD↑, 2,   SOD2↓, 1,   Trx1↑, 1,   TrxR↓, 2,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1,   AIF↑, 1,   BOK↑, 1,   CDC2↓, 4,   CDC2↑, 1,   CDC25↓, 6,   EGF↓, 2,   FGFR1↓, 1,   MEK↓, 2,   MMP↓, 25,   MPT↑, 1,   mtDam↑, 2,   OCR↓, 2,   Raf↓, 1,   XIAP↓, 8,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ACC↑, 2,   AKT1↓, 1,   ALAT↝, 1,   AMPK↑, 6,   CAIX↓, 1,   CAIX↑, 1,   cMyc↓, 8,   cMyc↑, 1,   p‑cMyc↑, 1,   FASN↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 5,   HK2↓, 2,   HMG-CoA↓, 1,   lactateProd↓, 2,   LDH↓, 2,   LDHA↓, 1,   LDL↓, 2,   NADPH↓, 1,   PCK1↓, 1,   PDH↝, 1,   PDK1↓, 1,   PI3k/Akt/mTOR↝, 1,   PIK3CA↓, 1,   PKM2↓, 1,   PPARγ↓, 1,   PPARγ↑, 2,   SIRT1↓, 2,   SIRT1↑, 1,   SREBP1↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 25,   Akt↑, 1,   p‑Akt↓, 4,   APAF1↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 25,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 5,   Bak↑, 5,   BAX↑, 50,   Bax:Bcl2↑, 3,   Bcl-2↓, 35,   Bcl-2↑, 1,   Bcl-xL↓, 6,   BID↓, 1,   BID↑, 2,   BIM↑, 5,   Casp↑, 7,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 29,   cl‑Casp3↑, 4,   Casp7↑, 3,   Casp8↑, 7,   cl‑Casp8↑, 3,   Casp9↑, 22,   cl‑Casp9↑, 5,   proCasp9↓, 1,   cFLIP↓, 2,   Chk2↑, 1,   Cyt‑c↑, 25,   Diablo↑, 3,   DR4↑, 2,   DR5↑, 12,   FADD↑, 2,   Fas↑, 13,   FasL↑, 2,   Ferroptosis↑, 2,   hTERT/TERT↓, 5,   IAP1↓, 1,   IAP2↓, 1,   iNOS↓, 3,   JNK↓, 2,   JNK↑, 5,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 6,   Mcl-1↓, 6,   MDM2↓, 4,   Myc↓, 2,   NAIP↓, 1,   NICD↓, 1,   NOXA↑, 1,   p27↑, 7,   p38↓, 1,   p38↑, 4,   p‑p38↓, 1,   PUMA↑, 1,   survivin↓, 10,   Telomerase↓, 3,   TRAIL↑, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 1,   RET↓, 1,   Sp1/3/4↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 3,   p‑H3↓, 1,   other↓, 1,   pRB↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 8,   eIF2α↓, 1,   eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 7,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 4,   BNIP3↑, 2,   LC3A↑, 1,   LC3B-II↑, 1,   LC3II↑, 6,   LC3s↑, 1,   p62↓, 3,   p62↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair ⓘ

ATM↑, 2,   CHK1↑, 1,   DNAdam↑, 10,   DNArepair↑, 1,   DNMTs↓, 1,   p16↑, 1,   P53?, 1,   P53↑, 19,   PARP↑, 1,   cl‑PARP↑, 13,   PCNA↓, 6,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 3,   CDK2↓, 14,   CDK2↑, 2,   CDK4↓, 16,   CDK4↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 20,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE/CCNE↑, 2,   cycE1↓, 1,   E2Fs↓, 1,   P21↑, 17,   RB1↑, 2,   Securin↓, 1,   TumCCA↓, 3,   TumCCA↑, 30,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD133↓, 2,   CD44↓, 3,   cFos↓, 3,   CIP2A↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   CSCs↓, 5,   EMT↓, 15,   EMT↑, 3,   ERK↓, 14,   ERK↑, 2,   p‑ERK↓, 2,   Gli1↓, 2,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   HMGCR↓, 1,   IGF-1↓, 2,   IGF-1R↓, 2,   Let-7↑, 1,   miR-34a↑, 1,   mTOR↓, 16,   p‑mTOR↓, 2,   mTORC1↓, 3,   mTORC2↓, 3,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 5,   NOTCH1↓, 4,   NOTCH1↑, 1,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 19,   PI3K↑, 1,   PTEN↑, 4,   RAS↓, 4,   RAS↑, 1,   Shh↓, 2,   SHP1↑, 1,   Smo↓, 2,   SOX2↓, 2,   STAT3↓, 12,   STAT3↑, 1,   p‑STAT3↓, 3,   STAT6↓, 1,   TAZ↓, 1,   TCF↑, 1,   TCF-4↓, 1,   TOP1↓, 2,   TOP2↓, 3,   TRPM7↓, 2,   TumCG↓, 6,   TumCG↑, 1,   Wnt↓, 14,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

AEG1↓, 1,   Akt2↓, 1,   AP-1↓, 4,   AXL↓, 1,   Ca+2↑, 10,   CAFs/TAFs↓, 1,   Cdc42↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 17,   F-actin↓, 1,   FAK↓, 4,   Fibronectin↓, 2,   Ki-67↓, 4,   LAMs↓, 1,   MET↓, 1,   miR-133a-3p↑, 1,   MMP1↓, 4,   MMP13↓, 3,   MMP2↓, 22,   MMP3↓, 3,   MMP7↓, 5,   MMP9↓, 24,   MMPs↓, 5,   N-cadherin↓, 11,   PDGF↓, 2,   PKCδ↓, 3,   Rho↓, 2,   ROCK1↓, 2,   SMAD2↓, 1,   SMAD3↑, 1,   SMAD4↓, 1,   Snail↓, 8,   TET1↑, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 2,   TIMP2↓, 1,   TIMP2↑, 3,   TIMP3↑, 1,   Treg lymp↓, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 11,   TumCMig↓, 4,   TumCMig↑, 1,   TumCP↓, 15,   TumMeta↓, 15,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 10,   Vim↓, 15,   Zeb1↓, 1,   ZEB2↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 12,  

Angiogenesis & Vasculature ⓘ

angioG↓, 20,   angioG↑, 1,   ATF4↓, 1,   ATF4↑, 3,   EGFR↓, 9,   p‑EGFR↓, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 12,   NO↓, 2,   VEGF↓, 29,   VEGFR2↓, 6,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 1,   GLUT1↑, 1,   GLUT3↑, 1,   P-gp↓, 3,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   CD4+↑, 1,   COX2↓, 15,   CXCR4↓, 2,   FOXP3↓, 1,   IFN-γ↓, 1,   IL1↓, 2,   IL1β↓, 1,   IL6↓, 9,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 5,   JAK1↓, 1,   JAK2↓, 1,   MCP1↓, 1,   NF-kB↓, 36,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   p65↓, 2,   PD-1↓, 1,   PD-L1↓, 2,   PGE2↓, 3,   PSA↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TNF-α↓, 7,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,   CDK6↓, 5,   CDK6↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 10,   BioAv↑, 7,   BioAv↝, 4,   ChemoSen↓, 1,   ChemoSen↑, 23,   CYP1A2↓, 1,   Dose↑, 1,   Dose↝, 4,   Dose∅, 3,   eff↓, 4,   eff↑, 32,   eff↝, 3,   Half-Life↓, 4,   Half-Life↝, 2,   MDR1↓, 2,   P450↓, 1,   RadioS↑, 8,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

AFP↓, 2,   ALAT↝, 1,   ALP↝, 1,   AR↓, 3,   AST↝, 1,   BMPs↑, 1,   E6↓, 3,   E7↓, 3,   EGFR↓, 9,   p‑EGFR↓, 1,   Ferritin↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 9,   Ki-67↓, 4,   LDH↓, 2,   Myc↓, 2,   PD-L1↓, 2,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 11,   AntiTum↑, 2,   cardioP↑, 2,   chemoP↑, 4,   ChemoSideEff↓, 3,   hepatoP↑, 2,   NDRG1↑, 1,   neuroP↑, 1,   OS↑, 4,   Pin1↓, 2,   QoL↑, 1,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 3,   Risk↓, 2,   toxicity↓, 1,   toxicity↑, 1,   TumVol↓, 1,   TumW↓, 1,   Weight↑, 1,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 452

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 13,   Catalase↑, 8,   Ferroptosis↓, 1,   GPx↑, 4,   GSH↑, 6,   GSR↑, 4,   GSTA1↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 4,   MDA↓, 1,   NRF2↑, 6,   ROS↓, 12,   SOD↑, 7,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 4,   p‑AMPK↑, 1,   LDH↓, 2,   LDHA↑, 1,   lipidLev↓, 1,   NADPH↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 1,   BAX↓, 1,   Casp3↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,  

DNA Damage & Repair ⓘ

p16↓, 1,   P53↓, 1,  

Cell Cycle & Senescence ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,  

Migration ⓘ

p‑Rac1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 2,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IKKα↑, 1,   IL10↓, 1,   IL2↓, 1,   IL6↓, 1,   Inflam↓, 8,   Inflam↑, 1,   NF-kB↓, 1,   PGE2↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 6,   BioAv↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 4,   ALP↓, 3,   AST↓, 4,   IL6↓, 1,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 4,   chemoP↑, 2,   cognitive↑, 2,   hepatoP↑, 7,   neuroP↑, 10,   RenoP↑, 3,   Risk↓, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity∅, 1,  
Total Targets: 69

Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX
7 Propolis -bee glue
6 Fisetin
4 Baicalein
4 Luteolin
4 Quercetin
4 Silymarin (Milk Thistle) silibinin
4 Thymoquinone
3 Ashwagandha(Withaferin A)
3 Carvacrol
3 Thymol-Thymus vulgaris
3 Lycopene
3 Resveratrol
2 Allicin (mainly Garlic)
2 Artemisinin
2 Betulinic acid
2 Caffeic acid
2 Chrysin
2 Curcumin
2 Ellagic acid
2 HydroxyTyrosol
2 Juglone
2 Oleuropein
2 Rosmarinic acid
2 Sulforaphane (mainly Broccoli)
1 Astragalus
1 Atorvastatin
1 beta-glucans
1 immunotherapy
1 Berbamine
1 Berberine
1 Emodin
1 Ferulic acid
1 Gambogic Acid
1 Honokiol
1 Melatonin
1 Phenylbutyrate
1 Piperlongumine
1 Psoralidin
1 Pterostilbene
1 Shikonin
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:26  Cells:%  prod#:%  Target#:26  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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