toxicity Cancer Research Results

toxicity, toxicity: Click to Expand ⟱
Source:
Type:
Toxicity
Var, Various Cancer: Click to Expand ⟱
Cyclooxygenase (COX)-2 overexpression has been noted in various cancers. PI3Ks/AKT pathways are over-activated in several types of cancers.
EGFR altered activity has been noted in various pathological conditions. However, its regulation is an important step in the inhibition of cancer. In this regard, EGCG shows a pivotal role in the inhibition of EGFR activity.
Activating protein-1 transcription factor has been associated with pathogenesis including cancer.
Activation of the sonic hedgehog (Shh) pathway is required for the growth of numerous tissues and organs and recent evidence indicates that this pathway is often recruited to stimulate growth of cancer stem cells (CSCs) and to orchestrate the reprogramming of cancer cells via epithelial mesenchymal transition (EMT). Increased expression of Nanog has been associated with the aggressive nature of certain cancers, highlighting its role in promoting cancer stem cell characteristics.
The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression of a variety of tumors.
The process of cell apoptosis is often accompanied by the destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Human malignancies frequently exhibit mutations in the TGF-β pathway, and overactivation of this system is linked to tumor growth by promoting angiogenesis and inhibiting the innate and adaptive antitumor immune responses50.
Several studies have demonstrated that high cyclin D1 expression was observed in cancers including breast, lung, prostate, lymph node and colorectal cancers [23–25].
The oncogene c-myc, which is frequently over-expressed in cancer cells, is involved in the transactivation of most of the glycolytic enzymes including lactate dehydrogenase A (LDHA) and the glucose transporter GLUT1 [51,52]. Thus, c-myc activation is a likely candidate to promote the enhanced glucose uptake and lactate release in the proliferating cancer cell.
Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin’s overexpression in cancer correlates well with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure.
Heat shock proteins (HSPs) are normally induced under environmental stress to serve as chaperones for maintenance of correct protein folding but they are often overexpressed in many cancers, including breast cancer.
Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 and NQO1-targeted drug delivery have been active areas of research.
Since increased Nrf2 gene expression is one of the main mechanisms of cancer cells in resisting chemotherapeutic drugs and survival in oxidative conditions; finding compounds with the ability to suppress Nrf2 gene expression with minimum side effects can be considered an important strategy for increasing the sensitivity of cancer cells to chemotherapy.
Overexpression of c-met stimulates proliferation, migration and invasion in various types of cancer including prostate cancer.
Overexpression of TGFα and EGFR by many carcinomas correlates with the development of cancer metastasis, resistance to chemotherapy and poor prognosis.
More than 50% of human cancers have a mutated nonfunctional p53.


Scientific Papers found: Click to Expand⟱
5281- 3BP,    A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
- Case Report, Var, NA
Glycolysis↓, mt-OXPHOS↓, ATP↓, selectivity↑, toxicity↝, OS↑, QoL↑,
5257- 3BP,    Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
- Review, Var, NA
Glycolysis↓, mt-OXPHOS↓, HK2↓, Cyt‑c↑, Casp3↓, Bcl-2↓, Mcl-1↓, GAPDH↓, LDH↓, PDH↓, TCA↓, GlutaM↓, GSH↓, ATP↓, mitResp↓, ROS↑, ChemoSen↑, toxicity↝,
5264- 3BP,    Candidate cancer drug suspected after death of three patients at an alternative medicine clinic
- Review, Var, NA
toxicity↑, Glycolysis↓, eff↑, OS↑, QoL↑, toxicity↝,
5366- AV,    Aloe vera: A review of toxicity and adverse clinical effects
- Review, Var, NA
*Dose↝, *toxicity↝, tumCV↓, *AntiAg↑,
5589- BetA,    Advancements in Betulinic Acid-Loaded Nanoformulations for Enhanced Anti-Tumor Therapy
- Review, Var, NA
BioAv↓, toxicity↝, BioAv↑, Half-Life↑,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1↓, RadioS↑, PhotoS↑, toxicity↝,
5682- BML,    A novel treatment of bromelain and acetylcysteine (BromAc) in patients with peritoneal mucinous tumours: A phase I first in man study
- Human, Var, NA
Dose↝, toxicity↝, eff↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
5829- CAP,    Anti-cancer activity of capsaicin and its analogs in gynecological cancers
- Review, Var, NA
Pain↓, BioAv↓, toxicity↝, toxicity↓,
5862- carbop,  Cisplatin,    Molecular Mechanisms of Resistance and Toxicity Associated with Platinating Agents
- Review, Var, NA
DNAdam↑, ER Stress↑, UPR↑, ATF4↑, ATF6↑, XBP-1↑, GRP78/BiP↑, NP/CIPN↝, toxicity↝, eff↑, TrxR1⇅,
5929- Catechins,    Phase I trial of oral green tea extract in adult patients with solid tumors
- Trial, Var, NA
Dose↑, toxicity↝,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
4769- CoQ10,    CoQ10 Is Key for Cellular Energy and Cancer Support
- Review, Var, NA
Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
5193- dietMet,  Rad,    A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy
- Trial, Var, NA
toxicity↝, other↝,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
4024- FulvicA,    ANTI-CARCINOGENIC ACTIVITY OF SHILAJIT REGARDING TO APOPTOSIS ASSAY IN CANCER CELLS: A SYSTEMATIC REVIEW OF IN-VITRO STUDIES
- Review, Var, NA
*Inflam↓, *antiOx↑, TumCG↓, tumCV↓, ROS↑, ChemoSen↑, toxicity↝,
2180- itraC,    Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent
- Review, Var, NA
Dose↝, toxicity↝, BioAv↑, Half-Life↝, BioAv↑, Dose↝, HH↓, TumAuto↑, Akt↓, mTOR↓, angioG↓, MDR1↓, TumCP↓, eff↑,
1898- MeJa,    Methyl jasmonate and its potential in cancer therapy
- Review, Var, NA
ROS↑, selectivity↑, toxicity↝,
2038- PB,    A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies
- Trial, Var, NA
Dose∅, *toxicity↝, BioAv↑, SD↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
5284- Ramu,    https://pmc.ncbi.nlm.nih.gov/articles/PMC4131847/
- Review, Var, NA
VEGFR2↓, OS↑, angioG↓, toxicity↝, ChemoSen↑, Dose↝,
1749- RosA,    Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer
- Review, Var, NA
antiOx↑, eff↑, *toxicity↝, *BioAv↑, *ROS↓, SOD↑, Catalase↑, GPx↑, lipid-P↓, P450↓, chemoP↑, hepatoP↑, ChemoSen↑,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
2548- SDT,    Sonoporation, a Novel Frontier for Cancer Treatment: A Review of the Literature
- Review, Var, NA
sonoP↑, Dose↝, eff↓, Dose↝, BioEnh↑, toxicity↝,
4608- SeNPs,    Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
- Review, Var, NA - NA, AD, NA
*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, eff↑, other↝, *eff↑, *Aβ↓, *eff↑,
4740- SSE,    Optimising Selenium for Modulation of Cancer Treatments
- Review, Var, NA
*selenoP↑, *Dose↓, Risk↓, *toxicity↝, Dose↑, chemoP↑, radioP↑,
5074- SSE,    Application of Sodium Selenite in the Prevention and Treatment of Cancers
- Review, Var, NA
Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,
5073- SSE,    Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
- Trial, Var, NA
AntiTum↑, ChemoSen↑, Dose↑, Half-Life↝, toxicity↝, toxicity↝,
5085- SSE,    Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites
- Review, Var, NA
toxicity↝, Half-Life↝, ROS↑, Thiols↓, NADPH↓, toxicity↝, other↝,

Showing Research Papers: 1 to 31 of 31

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 31

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   GPx↑, 1,   GSH↓, 3,   HO-1↓, 1,   Iron↑, 1,   lipid-P↓, 1,   NQO1↓, 1,   NRF2↓, 2,   mt-OXPHOS↓, 2,   ROS↑, 13,   SOD↓, 1,   SOD↑, 1,   Thiols↓, 1,   TrxR1⇅, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 5,   Insulin↓, 1,   mitResp↓, 1,   mitResp↑, 1,   MMP↓, 3,   MPT↑, 1,   mtDam↑, 1,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

CYP3A4↓, 1,   GAPDH↓, 1,   GlutaM↓, 1,   Glycolysis↓, 5,   HK2↓, 2,   LDH↓, 1,   NADPH↓, 1,   PDH↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 5,   Apoptosis↑, 5,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↓, 1,   Cyt‑c↑, 2,   DR4↑, 1,   Fas↑, 1,   hTERT/TERT↓, 1,   MAPK↓, 2,   Mcl-1↓, 1,   necrosis↑, 1,   p27↑, 1,   survivin↓, 1,   Telomerase↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   other↝, 4,   PhotoS↑, 1,   SD↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 5,  

DNA Damage & Repair ⓘ

DNAdam↑, 3,   DNArepair↑, 1,   P53↓, 1,   P53↑, 1,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CSCs↓, 3,   CSCsMark↓, 1,   EIF4E↓, 1,   EMT↓, 5,   ERK↓, 1,   HDAC↓, 1,   HH↓, 1,   IGF-1↑, 1,   mTOR↓, 2,   mTORC1↓, 1,   PI3K↓, 3,   STAT3↓, 1,   p‑STAT3↑, 1,   TumCG↓, 4,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

Ca+2↑, 2,   CDKN1C↑, 1,   CLDN1↓, 1,   E-cadherin↑, 1,   ITGB1↓, 1,   ITGB6↓, 1,   MMP2↓, 3,   MMP9↓, 3,   MMPs↓, 2,   ROCK1↓, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 3,   TumMeta↓, 2,   Twist↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 1,   Hif1a↓, 2,   VEGF↓, 1,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,   sonoP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   Imm↑, 2,   Inflam↓, 2,   JAK2↓, 1,   NF-kB↓, 4,   p‑NF-kB↓, 1,   NK cell↑, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 6,   BioAv↝, 1,   BioEnh↑, 2,   ChemoSen↑, 14,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 5,   Dose↝, 9,   Dose∅, 1,   eff↓, 1,   eff↑, 12,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 3,   MDR1↓, 1,   MRP1↓, 1,   P450↓, 2,   RadioS↑, 5,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

BG↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 5,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   NP/CIPN↝, 1,   OS↑, 4,   Pain↓, 1,   QoL↑, 2,   QoL∅, 1,   radioP↑, 1,   Risk↓, 4,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 24,   TumVol↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 171

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx1↑, 1,   GSTs↑, 1,   HDL↑, 1,   OXPHOS↑, 1,   ROS↓, 4,   selenoP↑, 2,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,  

Cell Death ⓘ

MAPK↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 2,  

Proliferation, Differentiation & Cell State ⓘ

PTEN↑, 1,  

Migration ⓘ

AntiAg↑, 2,  

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,   Inflam↓, 3,   NF-kB↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 5,   Dose↓, 1,   Dose↝, 4,   eff↑, 2,   Half-Life↝, 1,   P450↓, 1,  

Functional Outcomes ⓘ

radioP↑, 1,   toxicity↓, 2,   toxicity↝, 9,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 32

Scientific Paper Hit Count for: toxicity, toxicity
4 Selenite (Sodium)
3 3-bromopyruvate
1 Aloe anthraquinones
1 Betulinic acid
1 Brucea javanica
1 brusatol
1 Bromelain
1 borneol
1 Capsaicin
1 carboplatin
1 Cisplatin
1 Catechins
1 Celecoxib
1 Chrysin
1 Coenzyme Q10
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 Radiotherapy/Radiation
1 Disulfiram
1 immunotherapy
1 Shilajit/Fulvic Acid
1 itraconazole
1 Methyl Jasmonate
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Ramucirumab (CYRAMZA)
1 Rosmarinic acid
1 salinomycin
1 SonoDynamic Therapy UltraSound
1 Selenium NanoParticles
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:26  Cells:%  prod#:%  Target#:1025  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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