HMGCR Cancer Research Results

HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR): Click to Expand ⟱
Source:
Type:
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
– HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a critical step in the cholesterol biosynthesis pathway.
– Cholesterol is essential for maintaining cell membrane integrity and serves as a precursor for steroid hormones, which can influence tumor growth.

– In certain contexts, elevated HMGCR expression has been linked to more aggressive tumor phenotypes, increased proliferation, and, in some cases, poorer overall survival.
GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
5451- ATV,    In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U87MG - in-vitro, GBM, A172
TumAuto↑, CSCs↓, HMG-CoA↓, TumCP↓, tumCV↓, TumCCA↑, TumCG↓, HMGCR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

HMG-CoA↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   HMGCR↓, 1,   TumCG↓, 1,  

Migration ⓘ

TumCP↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:1133  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page