MARK4 Cancer Research Results

MARK4, Microtubule Affinity-Regulating Kinase 4: Click to Expand ⟱
Source:
Type:
MARK4 is involved in phosphorylating microtubule-associated proteins. This phosphorylation modulates microtubule stability and dynamics, which are important for processes like cell division, intracellular transport, and maintaining cell structure.
- Dysregulation of MARK4 has been observed in various cancers, contributing to tumor growth, invasion, and metastasis.
• Many studies have found that MARK4 is often upregulated in cancers such as breast cancer, glioma, and hepatocellular carcinoma.

• Higher expression of MARK4 in these settings has been associated with a poorer prognosis, including greater tumor aggressiveness and lower survival rates.
GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
3011- RosA,    Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition
- in-vitro, GBM, SH-SY5Y - in-vitro, Lung, A549 - in-vitro, Nor, HEK293 - in-vitro, Nor, MCF10
MARK4↓, p‑tau↓, selectivity↑, *toxicity∅,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

MARK4↓, 1,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: MARK4, Microtubule Affinity-Regulating Kinase 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:1178  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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