Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
308- Api,    Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling
- in-vitro, GBM, U87MG - in-vitro, GBM, U373MG
cMET↓, Akt↓, Nanog↓, SOX2↓,
569- ART/DHA,    Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3
- in-vitro, GBM, NA
TumCP↓, Apoptosis↑, TumCCA↑, Casp3↑, p‑Akt↓,
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,
5549- BBM,    Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells
- in-vitro, GBM, NA
eff?, tumCV↓, TumCG↓, ROS↑, P53↑, CSCs↓, CD133↓, ALDH1A1↓, Nanog↓, SOX2↓, OCT4↓, CDK1↓, CaMKII ↓, STAT3↓, Akt↓, ERK↓,
2757- BetA,    Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways
- in-vitro, GBM, U251
tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, Ferroptosis↑, HO-1↑, NRF2↑,
5886- CAR,    Inhibition of TRPM7 with carvacrol suppresses glioblastoma functions in vivo
- in-vivo, GBM, U87MG - in-vivo, GBM, U251
TRPM7↓, TumVol↓, p‑Akt↓, p‑GSK‐3β↑, Dose↝,
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5912- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, p‑Cofilin↑, RAS↓, MEK↓, MAPK↓, PI3K↓, Akt↓,
952- Cin,    Cinnamon Extract Reduces VEGF Expression Via Suppressing HIF-1α Gene Expression and Inhibits Tumor Growth in Mice
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U251 - in-vivo, Ovarian, SKOV3
VEGF↓, Hif1a↓, p‑STAT3↓, p‑Akt↓, angioG↓, TumCG↓, TumW↓, ascitic↓,
480- CUR,    Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells
- in-vitro, GBM, SNB19
TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, NEDD9↓, NOTCH1↓, p‑Akt↓,
1153- HNK,    Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, Bcl-2↓, EGFR↓, CD133↓, Nestin↓, Akt↓, ERK↓, Casp3↑, p‑STAT3↓, TumCG↓,
959- PACs,    Grape seed extract inhibits VEGF expression via reducing HIF-1α protein expression
- in-vitro, GBM, U251 - in-vitro, BC, MDA-MB-231
Hif1a↓, p‑Akt↓, p‑S6K↓, p‑S6↓, VEGF↓,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, eff↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,

Showing Research Papers: 1 to 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   HO-1↑, 2,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 3,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 3,   MMP↓, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

p‑S6↓, 1,   p‑S6K↓, 1,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 8,   p‑Akt↓, 7,   Apoptosis↑, 7,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 2,   Ferroptosis↑, 1,   MAPK↓, 2,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,   CaMKII ↓, 1,   p70S6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

HSF1↓, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   TumCCA↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD133↓, 2,   cMET↓, 1,   CSCs↓, 1,   EMT↓, 1,   ERK↓, 3,   FOXO1↓, 1,   p‑GSK‐3β↑, 1,   mTOR↓, 2,   Nanog↓, 2,   Nestin↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   p85S6K↓, 1,   PI3K↓, 4,   p‑PI3K↓, 1,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 2,   SOX2↓, 2,   STAT3↓, 2,   p‑STAT3↓, 2,   TRPM7↓, 3,   TumCG↓, 4,  

Migration ⓘ

p‑Cofilin↑, 2,   F-actin↓, 1,   MMP2↓, 3,   MMP9↓, 1,   NEDD9↓, 1,   TumCI↓, 5,   TumCMig↓, 6,   TumCP↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 1,   Hif1a↓, 2,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 2,   p65↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff?, 1,   eff↓, 1,   eff↑, 1,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ascitic↓, 1,   EGFR↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   chemoP↑, 1,   neuroP↑, 1,   toxicity↓, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 92

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

Inflam↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
3 Carvacrol
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Betulinic acid
1 Cinnamon
1 Curcumin
1 Honokiol
1 Proanthocyanidins
1 Rosmarinic acid
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:4  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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