G6PD Cancer Research Results
G6PD, Glucose-6-phosphate dehydrogenase: Click to Expand ⟱
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Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that plays a crucial role in the pentose phosphate pathway (PPP), a metabolic pathway that generates NADPH and pentoses from glucose-6-phosphate. G6PD is the first enzyme in the PPP and is responsible for catalyzing the conversion of glucose-6-phosphate to 6-phosphogluconate, producing NADPH in the process.
**** patients who receive intravenous ascorbate must be prescreened for glucose 6 phosphate dehydrogenase deficiency.
G6PD expression is often elevated in various cancers and is generally linked to poorer prognosis.
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GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
GBM, |
U87MG |
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in-vivo, |
GBM, |
NA |
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in-vitro, |
GBM, |
U251 |
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RIP1↑, RIP3↑, Glycolysis↓, G6PD↓, HK2↓, PKM2↓, H2O2↑, GSH↓, ROS↑,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
GSH↓, 1, H2O2↑, 1, ROS↑, 1,
Core Metabolism/Glycolysis ⓘ
G6PD↓, 1, Glycolysis↓, 1, HK2↓, 1, PKM2↓, 1,
Cell Death ⓘ
RIP1↑, 1,
Migration ⓘ
RIP3↑, 1,
Total Targets: 9
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: G6PD, Glucose-6-phosphate dehydrogenase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:27 Cells:% prod#:% Target#:808 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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