mPGES-1 Cancer Research Results

mPGES-1, Microsomal prostaglandin E synthase-1: Click to Expand ⟱
Source:
Type:
Microsomal prostaglandin E synthase-1 (mPGES-1) is an enzyme involved in the production of prostaglandin E2 (PGE2), a pro-inflammatory mediator that plays a role in various physiological and pathological processes, including cancer.
Expression is high in cancers and associated with poor prognosis and lower OS.
GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
7749- ISL,    Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
- in-vitro, GBM, U87MG
angioG↓, COX2/PTGS2↓, mPGES-1↓, CYP4A/CYP4A11/CYP4A22↓, FGF21↓, TGF-β↓, VEGF↓, miR-194↑, NEAT1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CYP4A/CYP4A11/CYP4A22↓, 1,   NEAT1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FGF21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

miR-194↑, 1,  

Migration(tgid=13) ⓘ

TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   mPGES-1↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: mPGES-1, Microsomal prostaglandin E synthase-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:899  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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