MDA Cancer Research Results

MDA, Serum malondialdehyde: Click to Expand ⟱
Source:
Type:
MDA : malondialdehyde. The level of oxidative stress can be measured by assessing the MDA levels.
Since MDA is highly cytotoxic and carcinogenic agent it is frequently used as a biomarker of oxidative stress during major health problems such as cancer, etc.
Malondialdehyde (MDA) is the most widely used agent to estimate the extent of lipid peroxidation. Timely diagnosis of the condition followed by supplementation with antioxidants like beta-carotene, pro-vitamin A, vitamin A, vitamin C, vitamin E, lipoic acid, zinc, selenium, and spirulina can prevent potentially malignant disorders.
MDA is a lipid peroxidation marker
GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
3345- ART/DHA,    Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
- in-vitro, GBM, NA
ROS↑, Ferroptosis↑, lipid-P↑, HSP70/HSPA5↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MDA↑, GSH↓, eff↑, GPx4↑,
739- Bor,    Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HMC3
TumCG↓, TumCP↓, TumCCA↑, PCBP1↓, GSH↓, GPx4↓, Beclin-1↑, MDA↑, ACSL4↑, Casp3↑, Casp7↑, Ferroptosis↑, *toxicity↓,
738- Bor,    Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways
- in-vitro, GBM, U251 - in-vitro, GBM, A172 - in-vitro, Nor, SVGp12
TumCP↓, GPx4↓, GSH↓, HSP70/HSPA5↓, NRF2↓, MDA↑, Casp3↑, Casp7↑, Ferroptosis↑, selectivity↑,
729- Bor,    Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies
- in-vitro, GBM, U87MG - in-vivo, Nor, HaCaT
TOS↑, TumCG↓, MDA↑, SOD↑, Catalase↑, TAC↓, GSH↓, BRAF↑, MAPK↓, PTEN↓, Raf↓, *toxicity↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   Ferroptosis↑, 3,   GPx4↓, 2,   GPx4↑, 1,   GSH↓, 4,   lipid-P↑, 1,   MDA↑, 4,   NRF2↓, 1,   ROS↑, 1,   SOD↑, 1,   TAC↓, 1,   TOS↑, 1,  

Mitochondria & Bioenergetics ⓘ

Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1,  

Cell Death ⓘ

Casp3↑, 2,   Casp7↑, 2,   Ferroptosis↑, 3,   MAPK↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

BRAF↑, 1,   PTEN↓, 1,   TumCG↓, 2,  

Migration ⓘ

PCBP1↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

BRAF↑, 1,  
Total Targets: 33

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 2,  
Total Targets: 1

Scientific Paper Hit Count for: MDA, Serum malondialdehyde
3 Boron
1 Artemisinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:570  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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