necrosis Cancer Research Results

necrosis, necrosis: Click to Expand ⟱
Source:
Type: type of cell death
Necrosis is a type of cell death that occurs when cells are damaged or injured, leading to the loss of cellular homeostasis and the eventual death of the cell. Necrosis is a non-programmed form of cell death, meaning that it is not a deliberate or controlled process, but rather a response to cellular damage or injury.
GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
571- ART/DHA,  TMZ,    Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence
- vitro+vivo, GBM, A172 - vitro+vivo, GBM, U87MG
HR↓, RAD51↓, Apoptosis↑, necrosis↑, ROS↑, ChemoSen↑,
5487- EP,    High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas
- in-vivo, GBM, NA
OS↑, CellMemb↑, Imm↑, Inflam↓, necrosis↑, Pyro↑, eff↑, IL2↑, IL6↑, IL17↑, IFN-γ↓,
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,
3138- VitC,    The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
- in-vitro, RCC, RCC4 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-435 - in-vitro, Ovarian, SKOV3 - in-vitro, Colon, SW48 - in-vitro, GBM, U251
eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

lipid-P↑, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 2,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

Warburg↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   lysoMP↑, 1,   MOMP↑, 1,   necrosis↑, 4,   Pyro↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

autoF↓, 1,   lysosome↝, 1,   MitoP↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   HR↓, 1,   PARP↑, 1,   RAD51↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,  

Migration ⓘ

Ca+2↑, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↓, 1,   IL17↑, 1,   IL2↑, 1,   IL6↑, 1,   Imm↑, 1,   Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   eff↑, 3,  

Clinical Biomarkers ⓘ

IL6↑, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 34

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: necrosis, necrosis
1 Artemisinin
1 temozolomide
1 Electrical Pulses
1 salinomycin
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:781  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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