CXCL12 Cancer Research Results

CXCL12, SDF–1: Click to Expand ⟱
Source:
Type:
SDF–1, also known as CXCL12, is a chemokine with key roles in cell signaling, migration, angiogenesis, and the regulation of the tumor microenvironment.

-SDF–1 is widely recognized for its role in tumor progression and metastasis. In many cancers—including breast, colorectal, lung, liver, and pancreatic cancers—increased expression of SDF–1 or hyperactivation of its receptor-mediated signaling is associated with more aggressive disease features and poorer patient outcomes.
GC, Gastric Adenocarcinoma: Click to Expand ⟱
Stomach/Gastric Cancer
Scientific Papers found: Click to Expand⟱
3169- Ash,    Withaferin A blocks formation of IFN-γ-induced metastatic cancer stem cells through inhibition of the CXCR4/CXCL12 pathway in the UP-LN1 carcinoma cell model
- in-vitro, GC, NA
CXCR4↓, CXCL12↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

CXCL12↓, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CXCL12, SDF–1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:28  Cells:%  prod#:%  Target#:1247  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page