| Source: |
| Type: |
| Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis. Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”. Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria. The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health. In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways. The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria. The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation. |
| Stomach/Gastric Cancer |
| 5356- | AL, | Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects |
| - | Review, | GC, | NA |
| 2655- | AL, | Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities |
| - | Review, | GC, | NA |
| 2631- | Api, | Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells |
| - | in-vivo, | GC, | NA | - | in-vitro, | GC, | AGS |
| 1079- | ART/DHA, | Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2 |
| - | in-vitro, | GC, | BGC-823 | - | in-vitro, | GC, | HGC27 | - | in-vitro, | GC, | MGC803 |
| 5501- | Ba, | Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review |
| - | Review, | GC, | NA |
| 1288- | Ba, | The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells |
| - | in-vitro, | GC, | SGC-7901 |
| 1395- | BBR, | Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation |
| - | in-vitro, | GC, | NA |
| 1394- | BBR, | DL, | Synergistic Inhibitory Effect of Berberine and d-Limonene on Human Gastric Carcinoma Cell Line MGC803 |
| - | in-vitro, | GC, | MGC803 |
| 2842- | FIS, | Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells |
| - | in-vitro, | GC, | AGS |
| 1927- | JG, | Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway |
| - | in-vitro, | GC, | SGC-7901 |
| 2913- | LT, | Luteolin induces apoptosis by impairing mitochondrial function and targeting the intrinsic apoptosis pathway in gastric cancer cells |
| - | in-vitro, | GC, | HGC27 | - | in-vitro, | BC, | MCF-7 | - | in-vitro, | GC, | MKN45 |
| 4783- | Lyco, | Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells |
| - | in-vitro, | GC, | AGS | - | in-vitro, | GC, | SGC-7901 | - | in-vitro, | Nor, | GES-1 |
| 4533- | MAG, | Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways |
| - | in-vitro, | GC, | SGC-7901 |
| 55- | QC, | Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling |
| - | in-vitro, | GC, | GCSCs |
| 1471- | SFN, | ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells |
| - | in-vitro, | GC, | AGS |
| 2227- | SK, | Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species |
| - | in-vitro, | GC, | BGC-823 | - | in-vitro, | GC, | SGC-7901 | - | in-vitro, | Nor, | GES-1 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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