SMAD3 Cancer Research Results

SMAD3, SMAD3: Click to Expand ⟱
Source:
Type:
Deletion or inhibition of Smad3 in the tumour microenvironment suppresses tumour growth, invasion and metastasis in two syngeneic mouse tumour models.
Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development.
GC, Gastric Adenocarcinoma: Click to Expand ⟱
Stomach/Gastric Cancer
Scientific Papers found: Click to Expand⟱
2763- BetA,    Betulinic Acid Inhibits the Stemness of Gastric Cancer Cells by Regulating the GRP78-TGF-β1 Signaling Pathway and Macrophage Polarization
- in-vitro, GC, NA
GRP78/BiP↓, TGF-β↓, ChemoSen↑, CSCs↓, SMAD2↓, SMAD3↓, OCT4↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Protein Folding & ER Stress ⓘ

GRP78/BiP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   OCT4↓, 1,  

Migration ⓘ

SMAD2↓, 1,   SMAD3↓, 1,   TGF-β↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SMAD3, SMAD3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:28  Cells:%  prod#:%  Target#:556  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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