cGAS–STING Cancer Research Results

cGAS–STING, GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING): Click to Expand ⟱
Source:
Type:
cGAS–STING pathway is primarily associated with neuroinflammation and neuronal damage.
-Studies show upregulated STING in microglia and astrocytes in AD models.
GC, Gastric Adenocarcinoma: Click to Expand ⟱
Stomach/Gastric Cancer
Scientific Papers found: Click to Expand⟱
7767- IBC,    Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway
- vitro+vivo, GC, NA
TumCG↓, ROS↑, DHODH↓, MMP↓, cGAS–STING↑, Imm↑, mtDam↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DHODH↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   mtDam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

cGAS–STING↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cGAS–STING, GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:28  Cells:%  prod#:%  Target#:1370  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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