β-TRCP Cancer Research Results

β-TRCP, beta-transducin repeat-containing protein: Click to Expand ⟱
Source:
Type:
β-TRCP (beta-transducin repeat-containing protein) is a protein that plays a crucial role in the regulation of various cellular processes, including cell cycle progression, apoptosis, and DNA damage response. It is a component of the SCF (Skp1-Cullin-F-box) complex, a type of E3 ubiquitin ligase that targets specific proteins for degradation by the proteasome.
Overexpression of β-TRCP has been associated with poor prognosis and increased tumor aggressiveness. Elevated expression in: breast, lung, colon, prostate, ovarian, pancreatic, GBM HCC, Esophageal, Stomach.
GC, Gastric Adenocarcinoma: Click to Expand ⟱
Stomach/Gastric Cancer
Scientific Papers found: Click to Expand⟱
1013- Lyco,    Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells
- in-vitro, GC, AGS
Apoptosis↑, DNAdam↑, Bax:Bcl2↑, ROS↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, APC↑, β-TRCP↑, cMyc↓, cycD1/CCND1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   β-TRCP↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑GSK‐3β↓, 1,  

Migration ⓘ

APC↑, 1,   β-catenin/ZEB1↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: β-TRCP, beta-transducin repeat-containing protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:28  Cells:%  prod#:%  Target#:751  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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