Database Query Results : , ,

GC, Gastric Adenocarcinoma: Click to Expand ⟱

Stomach/Gastric Cancer

Scientific Papers found: Click to Expand⟱

239-

AL,

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

in-vitro,

GC,

SGC-7901

 30ug/ml

Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,

246-

AL,

Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

in-vitro,

GC,

MGC803

 0-10ug/ml

Apoptosis↑, cl‑Casp3↑, p38↑, tumCV↓, BAX↑, Bcl-2↑,

249-

AL,

Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

in-vitro,

GC,

MGC803

  0.1, 1 and 10 μg/ml

Casp3↑, p38↑, BAX↑, Bcl-2↓, p38↑, MAPK↑,

2655-

AL,

Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

Review,

GC,

TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,

2647-

AL,

The Mechanism in Gastric Cancer Chemoprevention by Allicin

Review,

GC,

ChemoSen↓, TumCG↓, TumCCA↑, ER Stress↑, Apoptosis↑, Casp↑, DR5↑,

2667-

AL,

Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment

Review,

GC,

AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,

302-

ALA,

The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression

in-vitro,

GC,

AGS

in-vitro,

GC,

BGC-823

in-vitro,

GC,

MKN-28

MUC4↓, STAT3↓,

2631-

Api,

Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells

in-vivo,

GC,

mice

in-vitro,

GC,

AGS

ER Stress↑, Hif1a↓, EZH2↓, HDAC↓, TumAuto↑, p‑mTOR↓, AMPKα↑, GRP78/BiP↑, ROS↑, MMP↓, Ca+2↑, ATF4↑, CHOP↑,

1079-

ART/DHA,

Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2

in-vitro,

GC,

BGC-823

 20 mg/L

 20 mg/L @ 60hr

in-vitro,

GC,

HGC27

in-vitro,

GC,

MGC803

TumCP↓, Apoptosis↑, COX2↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, MMP↓,

4993-

ART/DHA,

Dihydroartemisinin inhibits galectin-1–induced ferroptosis resistance and peritoneal metastasis of gastric cancer via the Nrf2–HO-1 pathway

vitro+vivo,

GC,

Ferroptosis↑, NRF2↓, HO-1↓, PI3K↓, Akt↓, TumMeta↓,

3169-

Ash,

Withaferin A blocks formation of IFN-γ-induced metastatic cancer stem cells through inhibition of the CXCR4/CXCL12 pathway in the UP-LN1 carcinoma cell model

in-vitro,

GC,

CXCR4↓, CXCL12↓,

4809-

ASTX,

Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression

in-vitro,

GC,

AGS

50 and 100 μM significantly suppressed cell proliferation

could not reach IC50 even under 100 μM.

in-vitro,

GC,

MKN45

tumCV↓, TumCP↓, TumCCA↑, p‑ERK↓, p27↑, cycD1/CCND1↓, CDK4↓,

1032-

BA,

Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer

in-vivo,

GC,

AGS

human and mice

GutMicro↑, PD-L1↓, IL10↓, TumCG↓,

1288-

Ba,

The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells

in-vitro,

GC,

SGC-7901

0-60uM/L

TumCG↓, TumCCA↑, Apoptosis↑, MMP↓, Bcl-2↓, BAX↑,

2620-

Ba,

Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review

Review,

GC,

Hif1a↓, HK2↓, LDHA↓, PDK1↓, p‑Akt↓, PTEN↑, GlucoseCon↓, lactateProd↓, Glycolysis↓,

2295-

Ba,

5-FU,

Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway

in-vitro,

GC,

AGS

ChemoSen↑, HK2↓, LDHA↓, PDK1↓, Akt↓, PTEN↑, Hif1a↓, Glycolysis↓, ROS↑, CHOP↑,

2391-

Ba,

Scutellaria baicalensis and its flavonoids in the treatment of digestive system tumors

Review,

GC,

Hif1a↓, PKM2↓, RadioS↑, Glycolysis↓, PAK↓,

1392-

BBR,

Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress

in-vitro,

GC,

AGS

2.5, 5, 10, 20, 40 µM

in-vitro,

GC,

MKN45

TumCG↓, TumCMig↓, ROS↑, MDA↑, SOD↓, NRF2↓, HO-1↓, Hif1a↓, EMT↓, Snail↓, Vim↓,

1394-

BBR,

DL,

Synergistic Inhibitory Effect of Berberine and d-Limonene on Human Gastric Carcinoma Cell Line MGC803

in-vitro,

GC,

MGC803

eff↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, TumCCA↑,

1395-

BBR,

Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation

in-vitro,

GC,

20, 50, and 80 µM

Apoptosis↑, ROS↑, MMP↓, ATP↓, AMPK↑, TP53↑, p‑MAPK↓, p‑ERK↓,

1396-

BBR,

Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro

in-vitro,

GC,

SNU1041

in-vitro,

GC,

SNU5

tumCV↓, ROS↑, MMP1↓, MMP2↓, MMP9↓, MMP7∅,

956-

BBR,

Berberine inhibits HIF-1alpha expression via enhanced proteolysis

in-vitro,

Nor,

HUVECs

7.5uM/16hr

mice

in-vitro,

GC,

SCM1

Hif1a↓, angioG↓,

2763-

BetA,

Betulinic Acid Inhibits the Stemness of Gastric Cancer Cells by Regulating the GRP78-TGF-β1 Signaling Pathway and Macrophage Polarization

in-vitro,

GC,

GRP78/BiP↓, TGF-β↓, ChemoSen↑, CSCs↓, SMAD2↓, SMAD3↓, OCT4↓,

2741-

BetA,

Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress

in-vitro,

GC,

SNU16

in-vitro,

GC,

NCI-N87

in-vivo,

NA,

(40 mg/kg)

mice

TumCG↓, TumCMig↓, TumCI↓, N-cadherin↓, E-cadherin↑, EMT↓, Ki-67↓, MMP2↓,

1420-

Bos,

Acetyl-11-keto-β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway

vitro+vivo,

GC,

BGC-823

(0–50 µM for 24, 48, and 72 h). AKBA

TumCP↓, TumCG↓, PTEN↑, BAX↑, Bcl-2↓, p‑Akt↓, COX2↓,

939-

Catechins,

5-FU,

Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-Fluorouracil

vitro+vivo,

GC,

SNU620

lactateProd↓, ROS↑, tumCV↓, LDHA↓, mt-ROS↑, proApCas↑,

3258-

CHr,

PBG,

Chrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells

in-vitro,

GC,

MKN45

40 μM

TET1↑, Apoptosis↑, TumCI↓, TumCMig↓,

2803-

CHr,

5-FU,

Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells

in-vitro,

GC,

AGS

chrysin doses of 40, 50, 60 and 80 µM, and 5-FU doses of 20, 25, 30 and 40 µM,

ChemoSen↑, TumCCA↑, eff↑, MDR1↓,

1593-

Citrate,

Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?

in-vitro,

GC,

BGC-823

10mM

in-vitro,

GC,

SGC-7901

PFK↓, Glycolysis↓, tumCV↓, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, ATP↓, ChemoSen↑, Mcl-1↓, glucoNG↑, FBPase↑, OXPHOS↓, TCA↓, β-oxidation↓, HK2↓, PDH↓, ROS↑,

16-

CP,

Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis

in-vitro,

GC,

SGC-7901

HH↓, Gli1↓, EMT↓, N-cadherin↓, E-cadherin↑, Snail↓,

4708-

CUR,

Molecular mechanisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancers

Review,

GC,

chemoPv↑, AntiCan↑, *antiOx↑, *Inflam↓, miR-21↓, miR-34a↑, miR-200b↑, miR-27a-3p↓,

410-

CUR,

Nrf2 depletion enhanced curcumin therapy effect in gastric cancer by inducing the excessive accumulation of ROS

vitro+vivo,

GC,

AGS

mice

vitro+vivo,

GC,

HGC27

ROS↑, NRF2↑,

458-

CUR,

Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion

vitro+vivo,

GC,

SGC-7901

25 μM, 3, 5 and 7 days; 100 mg/kg, 2 weeks

Casp3↑, Apoptosis↑, TumCP↓,

453-

CUR,

Cellular uptake and apoptotic properties of gemini curcumin in gastric cancer cells

in-vitro,

GC,

AGS

10,- 100 µM, 24, 48 and 72 h; 50 mg/kg, 6weeks

Bcl-2↓, survivin↓, BAX↑, TumCCA↑,

454-

CUR,

Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway

in-vitro,

GC,

MGC803

5, 10, 15, 20, 40 and 60 μM, 24, 48 and 72 h

TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,

455-

CUR,

Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin

in-vitro,

GC,

SGC-7901

10, 20, 40 and 80 µM, 48 h

Shh↓, Gli1↓, FOXM1↓, β-catenin/ZEB1↓, TumCMig↓, Apoptosis↑, TumCCA↑, Wnt↓, EMT↓, E-cadherin↑, Vim↓,

456-

CUR,

Curcumin Promoted miR-34a Expression and Suppressed Proliferation of Gastric Cancer Cells

vitro+vivo,

GC,

SGC-7901

50 μM, 24, 48 and 96 h

miR-34a↑, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, Bcl-2↓, CDK4/6↓, cycD1/CCND1↓,

457-

CUR,

Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling

in-vitro,

GC,

SGC-7901

10, 20 and 40 μM, 24 h

in-vitro,

GC,

BGC-823

TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,

1444-

Deg,

Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer

in-vitro,

GC,

MKN-28

1uM 24hrs

cell line SNU-484

Casp9↑, Casp3↑, Hif1a↓, VEGF↓, TumCCA↑, TumCG↓, DNAdam↑, p‑Akt↓,

1607-

EA,

Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions

Review,

GC,

STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,

2147-

Ex,

The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis

Review,

GC,

Risk↓,

2842-

FIS,

Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells

in-vitro,

GC,

AGS

TumCCA↑, CDK2↓, P53↑, selectivity↑, MMP↓, DNAdam↑, cl‑PARP↑, mt-ROS↑, eff↓, survivin↓,

1115-

GA,

Gallic acid alleviates gastric precancerous lesions through inhibition of epithelial mesenchymal transition via Wnt/β-catenin signaling pathway

in-vivo,

GC,

GES-1

mice,induced precancerous lesions of gastric cancer cells (MC)

TumCP↓, TumCCA↑, Wnt/(β-catenin)↓, EMT↓,

802-

GAR,

Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway

in-vitro,

GC,

HGC27

TumCP↓, TumCI↓, Apoptosis↑, PI3K/Akt↓, Akt↓, p‑mTOR↓, cycD1/CCND1↓, MMP2↓, MMP9↓, BAX↑, Bcl-2↓,

4507-

GLA,

Effect of γ-Linolenic Acid on the Transcriptional Activity of the Her-2/neu (erbB-2) Oncogene

in-vitro,

BC,

BT474

in-vitro,

BC,

SkBr3

in-vitro,

BC,

MDA-MB-453

in-vitro,

Ovarian,

SKOV3

in-vitro,

GC,

NCI-N87

HER2/EBBR2↓,

2898-

HNK,

Honokiol Suppression of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastric Cancer Cell Biological Activity and Its Mechanism

in-vitro,

GC,

AGS

in-vitro,

GC,

NCI-N87

in-vitro,

BC,

MGC803

in-vitro,

GC,

SGC-7901

TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, HER2/EBBR2↓, TumCCA↑, PI3K↓, Akt↓, MMP9↓, P21↑,

2877-

HNK,

Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer

in-vitro,

GC,

AGS

HDAC3↓, NF-kB↓, CEBPB↓, ER Stress↑, EMT↓, Wnt↓, β-catenin/ZEB1↓,

1927-

JG,

Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway

in-vitro,

GC,

SGC-7901

5, 10, 15 and 20 μmol/L 24h

36.51 μmol/L (24h) and 25.37 μmol/L (48 h)

Apoptosis↑, ROS↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Casp3?, Bax:Bcl2↑,

2924-

LT,

Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1

in-vitro,

GC,

in-vivo,

NA,

p‑STAT3↓, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, HSP90↓,

2913-

LT,

Luteolin induces apoptosis by impairing mitochondrial function and targeting the intrinsic apoptosis pathway in gastric cancer cells

in-vitro,

GC,

HGC27

0, 10, 20, 30, 40, 50, 60, 70, and 80 µM) for 24 h or 48 h

in-vitro,

BC,

MCF-7

in-vitro,

GC,

MKN45

TumCP↓, MMP↓, Apoptosis↑, ROS↑, SOD↓, ATP↓, Bax:Bcl2↑, TumCCA↑,

4777-

Lyco,

Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells

in-vitro,

GC,

AGS

*antiOx↑, tumCV↓, DNAdam↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, ROS↓, NF-kB↓, COX2↓, EGFR↓, p38↓,

4794-

Lyco,

Anticancer Effect of Lycopene in Gastric Carcinogenesis

Review,

GC,

*AntiCan↑, *ROS↓, *GSH↑, *GPx↑, *GSTs↑, TumCG↓, Apoptosis↑, ERK↓, Bcl-2↓, BAX↑, Cyt‑c↑, TumCCA↑, *DNAdam↓,

4793-

Lyco,

Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells

in-vitro,

GC,

AGS

antiOx↑, AntiCan↑, ROS↓, JAK1↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, cycE/CCNE↓, TumCP↓, Risk↓,

4783-

Lyco,

Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells

in-vitro,

GC,

AGS

in-vitro,

GC,

SGC-7901

in-vitro,

Nor,

GES-1

TumCG↓, TumCCA↑, Apoptosis↑, MMP↓, selectivity↑, cycE1↓, TP53↑, *antiOx↑,

1013-

Lyco,

Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells

in-vitro,

GC,

AGS

Apoptosis↑, DNAdam↑, Bax:Bcl2↑, ROS↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, APC↑, β-TRCP↑, cMyc↓, cycD1/CCND1↓,

4533-

MAG,

Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways

in-vitro,

GC,

SGC-7901

AntiCan↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bax:Bcl2↑, MMP↓, Casp3↑, PI3K↓, Akt↓,

4518-

MAG,

Cisplatin,

Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells

in-vitro,

GC,

MKN45

ChemoSen↑, tumCV↓, BAX↑, Bcl-2↓, P21↑, P53↑, MMP9↓,

2375-

MET,

Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling

in-vitro,

GC,

SGC-7901

0-50mM

tumCV↓, TumCI↓, TumCMig↓, Apoptosis↑, PARP↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, COX2↓,

3498-

MF,

Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues

in-vitro,

GC,

Twenty-four cancerous gastric tissues and 24 noncancerous adjacent gastric tissues were obtained from patients with gastric cancer by surgical operation

*SOD↑, *MDA↓, SOD↓, GPx↓, MDA↑, Catalase↑,

4015-

MF,

Evaluation of the PTEN and circRNA-CDR1as Gene Expression Changes in Gastric Cancer and Normal Cell Lines Following the Exposure to Weak and Moderate 50 Hz Electromagnetic Fields

in-vitro,

GC,

AGS

in-vitro,

Nor,

HU02

*PTEN↑, PTEN↓, Dose↝,

217-

MFrot,

MF,

Effect of low-frequency rotary magnetic fields on advanced gastric cancer

in-vivo,

GC,

HL-60

 420 r/min, 0.4-T

in-vivo,

GC,

SK-HEP-1

OS↑, Pain↓, ChemoSideEff↓, Weight↑, Strength↑, Sleep↑,

1273-

Myr,

Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4

vitro+vivo,

GC,

Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,

1226-

OLST,

Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation

vitro+vivo,

GC,

PGM1∅, FASN↓, Apoptosis↑, lipidLev↑, GlucoseCon↑, eff↑,

1254-

PI,

VitC,

Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer regulates the ROS–STAT3 pathway

in-vivo,

GC,

15 µM PL and 3 mM

tumour xenograft

STAT3⇅, eff↑, ROS↑, Apoptosis↑,

1165-

PI,

Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells

in-vitro,

GC,

TMK-1

p38↓, IL6↓, STAT3↓,

1947-

PL,

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer

in-vitro,

GC,

SGC-7901

in-vitro,

GC,

TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,

2968-

PL,

Chit,

Preparation of piperlongumine-loaded chitosan nanoparticles for safe and efficient cancer therapy

in-vitro,

GC,

AGS

eff↑, Dose↝, ROS↑, BioAv↑,

4965-

PSO,

Cisplatin,

The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis

vitro+vivo,

GC,

HGC27

2.5 to 120 µM)

Xenograft experiments in nude mice

vitro+vivo,

GC,

MKN45

TumCP↓, TumCMig↓, TumCI↓, TumCG↓, *toxicity↓, eff↑, Ferroptosis↑, ACSL4↑, GPx4↓, ChemoSen↑, chemoP↑, AntiTum↑, Sepsis↓,

1238-

PTS,

Pterostilbene suppresses gastric cancer proliferation and metastasis by inhibiting oncogenic JAK2/STAT3 signaling: In vitro and in vivo therapeutic intervention

in-vitro,

GC,

in-vivo,

NA,

xenograft tumor model

TumCCA↑, TumCP↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, Weight∅, JAK2↓, STAT3↓,

55-

QC,

Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling

in-vitro,

GC,

GCSCs

Bcl-2↓, BAX↑, Cyt‑c↑, MMP↓, PI3K/Akt↓, Casp3↑, Casp9↑,

5026-

QC,

Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes

in-vitro,

GC,

SLC1A5↓, ROS↑, Iron↓, NRF2↓, GPx4↓, Ferroptosis↑,

101-

RES,

Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis

in-vitro,

GC,

SGC-7901

 10 uM

HH↓, Gli1↓, EMT↓, Snail↓, N-cadherin↓, E-cadherin↑,

4748-

Se,

Chemo,

antiOx,

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in gastric cancer patients receiving adjuvant oxaliplatin and capecitabine after gastrectomy: a retrospective pilot study

Trial,

GC,

injection of selenium (2,000 μg/day) before chemotherapy

28 patients receiving adjuvant capecitabine plus oxaliplatin

toxicity↓, chemoP∅, *neuroP↑, *Dose↝,

963-

SFN,

Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells

in-vitro,

CRC,

HCT116

12.5-50 µM sulforaphane

in-vitro,

GC,

AGS

Hif1a↓, VEGF↓, angioG↓, Akt∅, ERK∅,

3199-

SFN,

Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis

in-vitro,

GC,

CSCs↓, CD133↓, BMI1↓, Nanog↓, Nestin↓,

2405-

SFN,

Sulforaphane Targets the TBX15/KIF2C Pathway to Repress Glycolysis and Cell Proliferation in Gastric Carcinoma Cells

in-vitro,

GC,

SGC-7901

in-vitro,

GC,

BGC-823

TumCP↓, Glycolysis↓, TBX15↑, GlucoseCon↓, lactateProd↓, tumCV↓, PKM2↓, KIF2C↓,

1452-

SFN,

Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells

in-vitro,

GC,

AGS

MMP9↓, p38↓, ERK↓, AP-1↓, ROS↓, NF-kB↓, TumCI↓, MMP9↓, HDAC↓, Glycolysis↓, Hif1a↓, *memory↑, *cognitive↑,

1471-

SFN,

ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells

in-vitro,

GC,

AGS

TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,

3304-

SIL,

Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells

in-vitro,

GC,

AGS

0, 20, 40, 60, 80, 100 and 120 µg/ml for 24 h

in-vivo,

NA,

100 mg/kg silymarin injection group mice

BAX↑, p‑JNK↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Apoptosis↑, tumCV↓,

2234-

SK,

Shikonin Suppresses Cell Tumorigenesis in Gastric Cancer Associated with the Inhibition of c-Myc and Yap-1

in-vitro,

GC,

TumCP↓, TumCI↓, TumCMig↓, cMyc↓, YAP/TEAD↓,

2227-

SK,

Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species

in-vitro,

GC,

BGC-823

13.35uM

in-vitro,

GC,

SGC-7901

9.63uM

in-vitro,

Nor,

GES-1

>20 μM

selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,

1280-

SK,

Shikonin Induces Apoptotic Cell Death via Regulation of p53 and Nrf2 in AGS Human Stomach Carcinoma Cells

in-vitro,

GC,

AGS

35–250 nM

ROS↑, Casp3↑, P53↑, NRF2↓,

2199-

SK,

Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis

in-vitro,

GC,

ROS↑, lipid-P↑, Iron↑, MDA↑, GPx4↓, Ferritin↓, DLEU1↓, mTOR↓, Ferroptosis↑,

1192-

SM,

Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1

in-vitro,

GC,

AGS

 0.34, 3.36, 1.58, and 2.05 microM on AGS cells

in-vitro,

Liver,

HepG3

0.28, 3.18, 1.36, and 2.29 microM on Hep3B cells

Hif1a↓, VEGF↓,

383-

SNP,

In vitro and in vivo evaluation of anti-tumorigenesis potential of nano silver for gastric cancer cells

in-vitro,

GC,

MKN45

 22.4 µg/mL

Ki-67↓, TumCP↓, CD34↓, BAX↑,

4552-

SNP,

ART/DHA,

Green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract and the study of anti-cancer effect and apoptosis induction on gastric cancer cell line (AGS)

in-vitro,

GC,

AGS

AntiCan↑, Apoptosis↑, eff↑,

2091-

TQ,

Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells

in-vitro,

BC,

MCF-7

in-vitro,

GC,

AGS

Dose↝, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, HSP70/HSPA5↓,

2083-

TQ,

Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro

in-vitro,

GC,

HGC27

in-vitro,

GC,

BGC-823

in-vitro,

GC,

SGC-7901

in-vivo,

NA,

mouse

p‑STAT3↓, JAK2↓, c-Src↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, VEGF↓, Casp3?, Casp7?, Casp9?, *toxicity∅, TumVol↓,

4849-

Uro,

Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway

vitro+vivo,

GC,

TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, TumAuto↑, TumCG↓, chemoP↑, ChemoSen↑,

4846-

Uro,

Urolithin A exerts anti-tumor effects on gastric cancer via activating autophagy-Hippo axis and modulating the gut microbiota

in-vivo,

GC,

Subsequently, the in vivo anti-tumor effect of UroA was determined using a xenograft mouse model.

TumCG↓, Hippo↑, Warburg↓, Apoptosis↑, GutMicro↑,

3132-

VitC,

Vitamin C affects G0/G1 cell cycle and autophagy by downregulating of cyclin D1 in gastric carcinoma cells

in-vitro,

GC,

MKN45

TumCCA↑, cycD1/CCND1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 91

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Sepsis↓, 1,
Total Targets: 251

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 4, GPx↑, 1, GSH↑, 2, GSTs↑, 1, MDA↓, 1, NRF2↓, 1, ROS↓, 2, SOD↑, 1,

DNA Damage & Repair ⓘ

DNAdam↓, 1,

Proliferation, Differentiation & Cell State ⓘ

PTEN↑, 1,

Immune & Inflammatory Signaling ⓘ

Inflam↓, 3, NF-kB↓, 1,

Drug Metabolism & Resistance ⓘ

Dose↝, 1,

Clinical Biomarkers ⓘ

GutMicro↑, 1,

Functional Outcomes ⓘ

AntiCan↑, 1, cardioP↑, 1, cognitive↑, 1, hepatoP↑, 2, memory↑, 1, neuroP↑, 2, toxicity↓, 1, toxicity∅, 2,
Total Targets: 22

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:28  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : , ,

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned ⓘ

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Immune & Inflammatory Signaling ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

DNA Damage & Repair ⓘ

Proliferation, Differentiation & Cell State ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

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