Gli1 Cancer Research Results

Gli1, glioma-associated oncogene homolog 1: Click to Expand ⟱

Source:

Type: HH

Gli family zinc-finger transcription factors; GLI1‐dependent target genes (CyclinD1, Bcl‐2, Foxm1)

Glioma-associated oncogene homolog 1 (GLI1) is a transcription factor that plays a significant role in the Hedgehog signaling pathway, which is crucial for cell growth, differentiation, and tissue patterning during embryonic development.
GLI1 can promote tumor growth and survival by regulating the expression of genes involved in cell proliferation, apoptosis, and angiogenesis. Its overexpression has been associated with aggressive tumor behavior and poor prognosis in several cancer types.
ts overexpression is often associated with aggressive tumor behavior, poor prognosis, and resistance to therapy

BCC, Basal Cell Carcinomas: Click to Expand ⟱

Basal Cell Carcinomas:

Constitutive Hedgehog (HH) signaling underlies several human tumors, including basal cell carcinoma (BCC).
The evidence that sunlight enhances BCC risk is well accepted. In fact, a significant proportion of PTCH1 and p53 gene mutations in human BCCs are of the UVB-signature type (31–33).

Scientific Papers found: Click to Expand⟱

31-

GlaB,

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

in-vitro,

BCC,

HH↓, Gli1↓, PTCH1↓, CSCs↓,

115-

VitD3,

Vitamin D3 Inhibits Hedgehog Signaling and Proliferation in Murine Basal Cell Carcinomas

in-vivo,

RCC,

in-vivo,

BCC,

HH↓, GLI2↓, Shh↓, Gli1↓, Ki-67↓, TumCP↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1, Gli1↓, 2, HH↓, 2, PTCH1↓, 1, Shh↓, 1,

Migration ⓘ

GLI2↓, 1, Ki-67↓, 1, TumCP↓, 1,

Clinical Biomarkers ⓘ

Ki-67↓, 1,
Total Targets: 9

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Gli1, glioma-associated oncogene homolog 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells