HH Cancer Research Results

HH, Hedgehog signaling: Click to Expand ⟱

Source: CGL-CF

Type: HH

Sonic hedgehog, Shh; Indian hedgehog, Ihh; Desert hedgehog, Dhh ; Hh signaling pathway is able to regulate the EMT. Hh signaling-related factors, SHH, SMO and GLI1.
Hedgehog signaling is a crucial pathway in embryonic development and tissue homeostasis, but its dysregulation has been implicated in various cancers. The Hedgehog (Hh) pathway is activated by the binding of Hedgehog ligands (such as Sonic Hedgehog, Indian Hedgehog, and Desert Hedgehog) to their receptors, primarily Patched (PTCH) and Smoothened (SMO).

-Hedgehog pathway is crucial for the maintenance of stem cell populations. When deregulated, it can help sustain cancer stem cells (CSCs) that possess self-renewal properties, drive tumor recurrence, and confer resistance to conventional therapies.

-Inhibitors of the pathway, such as vismodegib and sonidegib, have been developed and are used in clinical settings, particularly for treating advanced BCC and other Hedgehog-dependent tumors.

BCC, Basal Cell Carcinomas: Click to Expand ⟱

Basal Cell Carcinomas:

Constitutive Hedgehog (HH) signaling underlies several human tumors, including basal cell carcinoma (BCC).
The evidence that sunlight enhances BCC risk is well accepted. In fact, a significant proportion of PTCH1 and p53 gene mutations in human BCCs are of the UVB-signature type (31–33).

Scientific Papers found: Click to Expand⟱

31-

GlaB,

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

in-vitro,

BCC,

HH↓, Gli1↓, PTCH1↓, CSCs↓,

115-

VitD3,

Vitamin D3 Inhibits Hedgehog Signaling and Proliferation in Murine Basal Cell Carcinomas

in-vivo,

RCC,

in-vivo,

BCC,

HH↓, GLI2↓, Shh↓, Gli1↓, Ki-67↓, TumCP↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1, Gli1↓, 2, HH↓, 2, PTCH1↓, 1, Shh↓, 1,

Migration ⓘ

GLI2↓, 1, Ki-67↓, 1, TumCP↓, 1,

Clinical Biomarkers ⓘ

Ki-67↓, 1,
Total Targets: 9

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: HH, Hedgehog signaling

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells