PTCH1 Cancer Research Results

PTCH1, 12-transmembrane cell surface receptor Patched1: Click to Expand ⟱
Source: CGL-Driver
Type: TSG Gene
When not bound by Hh ligands, PTCH1 restrains the activity of Smo. The protein functions as a receptor protein for sonic hedgehog, desert hedgehog, and indian hedgehog proteins.
PTCH1 (Patched 1) is a gene that plays a crucial role in the Hedgehog signaling pathway, which is important for cell growth, differentiation, and tissue patterning during embryonic development. Mutations in the PTCH1 gene are associated with several types of cancer.

PTCH1 and PTCH2 act as tumor suppressors by maintaining control over Hedgehog signaling. Their loss—whether by mutation or reduced expression—leads to unchecked pathway activation, supporting cell proliferation and survival. Such abnormalities are associated with a more aggressive tumor phenotype and poorer clinical outcomes in cancers where the Hedgehog pathway is a driver of tumorigenesis.
BCC, Basal Cell Carcinomas: Click to Expand ⟱
Basal Cell Carcinomas: 
Constitutive Hedgehog (HH) signaling underlies several human tumors, including basal cell carcinoma (BCC).
The evidence that sunlight enhances BCC risk is well accepted. In fact, a significant proportion of PTCH1 and p53 gene mutations in human BCCs are of the UVB-signature type (31–33).


Scientific Papers found: Click to Expand⟱
31- GlaB,    Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
- in-vitro, BCC, NA
HH↓, Gli1↓, PTCH1↓, CSCs↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   Gli1↓, 1,   HH↓, 1,   PTCH1↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PTCH1, 12-transmembrane cell surface receptor Patched1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:3  Cells:%  prod#:%  Target#:266  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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