GLI3 Cancer Research Results

GLI3, GLI3: Click to Expand ⟱
Source:
Type:
GLI1, GLI2, and GLI3 are key downstream effectors of the Hh signaling pathway, acting as nuclear transcription factors that bind to promoters to regulate target gene expression. Highly expressed genes in human gliomas.
BCC, Basal Cell Carcinomas: Click to Expand ⟱
Basal Cell Carcinomas: 
Constitutive Hedgehog (HH) signaling underlies several human tumors, including basal cell carcinoma (BCC).
The evidence that sunlight enhances BCC risk is well accepted. In fact, a significant proportion of PTCH1 and p53 gene mutations in human BCCs are of the UVB-signature type (31–33).


Scientific Papers found: Click to Expand⟱
7991- itraC,    A Phase II Trial of Perioperative Oral Itraconazole for the Management of Low-Risk Basal Cell Carcinoma
- Trial, BCC, NA
Smo↓, Dose↓, TumVol↓, Endoglin↓, angioG↓, toxicity↝, GLI3↓, toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Smo↓, 1,  

Migration(tgid=13) ⓘ

GLI3↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Endoglin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GLI3, GLI3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:3  Cells:%  prod#:%  Target#:354  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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