Ki-67 Cancer Research Results

Ki-67, Ki-67 protein: Click to Expand ⟱

Source:

Type: proliferation marker

A high Ki-67 proliferation index means many cells are dividing quickly and that the cancer is likely to grow and spread.
Markers of proliferation index (Ki-67)

• Ki-67 serves primarily as a proliferation marker: higher levels are generally indicative of aggressive disease and poorer outcomes across many cancer types.
• While Ki-67 itself is not considered a driver of tumorigenesis, its expression mirrors the high proliferative activity associated with protumoral behavior.
• It is widely used in clinical practice to aid in tumor grading, prognostication, and treatment planning.

BCC, Basal Cell Carcinomas: Click to Expand ⟱

Basal Cell Carcinomas:

Constitutive Hedgehog (HH) signaling underlies several human tumors, including basal cell carcinoma (BCC).
The evidence that sunlight enhances BCC risk is well accepted. In fact, a significant proportion of PTCH1 and p53 gene mutations in human BCCs are of the UVB-signature type (31–33).

Scientific Papers found: Click to Expand⟱

115-

VitD3,

Vitamin D3 Inhibits Hedgehog Signaling and Proliferation in Murine Basal Cell Carcinomas

in-vivo,

RCC,

in-vivo,

BCC,

HH↓, GLI2↓, Shh↓, Gli1↓, Ki-67↓, TumCP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1, HH↓, 1, Shh↓, 1,

Migration ⓘ

GLI2↓, 1, Ki-67↓, 1, TumCP↓, 1,

Clinical Biomarkers ⓘ

Ki-67↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Ki-67, Ki-67 protein

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells