Cancer Database Query Results

BCC, Basal Cell Carcinomas: Click to Expand ⟱
Basal Cell Carcinomas: 
Constitutive Hedgehog (HH) signaling underlies several human tumors, including basal cell carcinoma (BCC).
The evidence that sunlight enhances BCC risk is well accepted. In fact, a significant proportion of PTCH1 and p53 gene mutations in human BCCs are of the UVB-signature type (31–33).


Scientific Papers found: Click to Expand⟱
5342- Ajoene,    The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis
- in-vivo, BCC, NA
TumVol↓, Bcl-2↓, Apoptosis↑,
31- GlaB,    Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
- in-vitro, BCC, NA
HH↓, Gli1↓, PTCH1↓, CSCs↓,
7991- itraC,    A Phase II Trial of Perioperative Oral Itraconazole for the Management of Low-Risk Basal Cell Carcinoma
- Trial, BCC, NA
Smo↓, Dose↓, TumVol↓, Endoglin↓, angioG↓, toxicity↝, GLI3↓, toxicity↓,
7986- itraC,    Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma
- Trial, BCC, NA
Dose↝, TumCP↓, HH↓, TumVol↓, SD↑,
8015- itraC,    Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
- vitro+vivo, BCC, NA
HH↓, Dose↝, CYP51/14LDM↓, Gli1↓,
115- VitD3,    Vitamin D3 Inhibits Hedgehog Signaling and Proliferation in Murine Basal Cell Carcinomas
- in-vivo, RCC, NA - in-vivo, BCC, NA
HH↓, GLI2↓, Shh↓, Gli1↓, Ki-67↓, TumCP↓,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CYP51/14LDM↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

SD↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   Gli1↓, 3,   HH↓, 4,   PTCH1↓, 1,   Shh↓, 1,   Smo↓, 1,  

Migration(tgid=13) ⓘ

GLI2↓, 1,   GLI3↓, 1,   Ki-67↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Endoglin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,   Dose↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 3,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:3  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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