cycE/CCNE Cancer Research Results

cycE/CCNE, Cyclin E: Click to Expand ⟱

Source:

Type:

Cyclin E regulates multiple downstream molecules, such as the retinoblastoma susceptibility gene (RB1) and the transcription factor E2F.
Cyclin E (Cyclin E1 and Cyclin E2) is the key regulator of the late G1 → S-phase transition.
Cyclin E is a prognostic marker in breast cancer, its altered expression increased with the increasing stage and grade of the tumor.
Cyclin E is a regulatory protein that plays a critical role in the cell cycle, particularly in the transition from the G1 phase to the S phase. Its expression levels can significantly influence cancer progression and patient prognosis.

Cyclin E expression is frequently elevated in various cancers and is generally associated with poor prognosis. Its role in promoting cell cycle progression makes it a potential biomarker for tumor aggressiveness and patient outcomes.

lymphoma, Lymphoma: Click to Expand ⟱

Lymphoma is a cancer of the lymphatic system.

Scientific Papers found: Click to Expand⟱

40-

QC,

Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells

in-vitro,

lymphoma,

U937

cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, CycB/CCNB1↑, Casp↑, Apoptosis↑, TumCCA↑, TumCP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1, Casp↑, 1,

Cell Cycle & Senescence ⓘ

CycB/CCNB1↑, 1, cycD1/CCND1↓, 1, cycE/CCNE↓, 1, E2Fs↓, 1, TumCCA↑, 1,

Migration ⓘ

TumCP↓, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: cycE/CCNE, Cyclin E

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells