Smad1 Cancer Research Results

Smad1, Smad1: Click to Expand ⟱

Source:

Type:

SMAD1 is a member of the SMAD family of proteins that are key intracellular mediators of the bone morphogenetic protein (BMP) signaling pathway. BMP/SMAD signaling plays a variety of roles in cell differentiation, proliferation, apoptosis, and migration.

In some cancers, altered SMAD1 expression has been reported. For example, reduced expression can compromise the tumor-suppressive BMP signaling in some contexts, potentially allowing for unchecked cell proliferation.
In other scenarios, particularly where BMP signaling promotes tumor progression or metastasis, elevated SMAD1 might be associated with a more aggressive phenotype.

In cancers where SMAD1 functions predominantly as a tumor suppressor (via proper BMP signaling), lower levels of SMAD1 might be associated with a poorer prognosis.
Conversely, in tumors where BMP signaling contributes to invasion or metastasis, higher SMAD1 expression may correlate with aggressive disease and worse outcomes.

lymphoma, Lymphoma: Click to Expand ⟱

Lymphoma is a cancer of the lymphatic system.

Scientific Papers found: Click to Expand⟱

3120-

VitC,

Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells

in-vitro,

lymphoma,

TET2↑, Smad1↑, ChemoSen↑, other↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Transcription & Epigenetics ⓘ

other↝, 1,

Migration ⓘ

Smad1↑, 1,

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1, TET2↑, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Smad1, Smad1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells