Casp8 Cancer Research Results
Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱
| Source: CGL-Driver Genes |
| Type: TSG |
Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.
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lymphoma, Lymphoma: Click to Expand ⟱
Lymphoma is a cancer of the lymphatic system.
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Scientific Papers found: Click to Expand⟱
| - |
in-vitro, |
lymphoma, |
JeKo-1 |
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TumCG↓, Apoptosis↑, selectivity↑, MMP↓, Casp3↑, Casp9↑, Casp8↑, Bax:Bcl2↑,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Mitochondria & Bioenergetics ⓘ
MMP↓, 1,
Cell Death ⓘ
Apoptosis↑, 1, Bax:Bcl2↑, 1, Casp3↑, 1, Casp8↑, 1, Casp9↑, 1,
Proliferation, Differentiation & Cell State ⓘ
TumCG↓, 1,
Drug Metabolism & Resistance ⓘ
selectivity↑, 1,
Total Targets: 8
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:30 Cells:% prod#:% Target#:44 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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