Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱

Source:

Type:

The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.

lymphoma, Lymphoma: Click to Expand ⟱

Lymphoma is a cancer of the lymphatic system.

Scientific Papers found: Click to Expand⟱

40-

QC,

Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells

in-vitro,

lymphoma,

U937

cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, CycB/CCNB1↑, Casp↑, Apoptosis↑, TumCCA↑, TumCP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1, Casp↑, 1,

Cell Cycle & Senescence ⓘ

CycB/CCNB1↑, 1, cycD1/CCND1↓, 1, cycE/CCNE↓, 1, E2Fs↓, 1, TumCCA↑, 1,

Migration ⓘ

TumCP↓, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Casp, caspase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells