PKM2:PKM1 Cancer Research Results

PKM2:PKM1, PKM2/PKM1 ratio: Click to Expand ⟱
Source:
Type:
PKM2/PKM1 ratio
-PKM (pyruvate kinase M) exists mainly as two splice isoforms: PKM1 and PKM2.
-PKM1 is constitutively active and typically found in tissues with high-energy demands (e.g., muscle, brain).
-PKM2 is less active under some conditions and is highly regulated; importantly, it is often upregulated in cancers.
- A higher PKM2/PKM1 ratio is thought to promote the “Warburg effect” (aerobic glycolysis) that benefits rapidly proliferating tumor cells by providing biosynthetic precursors even though it is less energy efficient.
-An increased PKM2/PKM1 ratio has been associated with enhanced tumor cell proliferation, survival, and metastasis.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
2314- Api,    Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis
- in-vitro, Colon, HCT116 - in-vitro, Colon, HT29 - in-vitro, Colon, DLD1
Glycolysis↓, PKM2:PKM1↓, β-catenin/ZEB1↓, cMyc↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   Glycolysis↓, 1,   PKM2:PKM1↓, 1,  

Migration ⓘ

β-catenin/ZEB1↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PKM2:PKM1, PKM2/PKM1 ratio
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:1291  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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