TumCMig Cancer Research Results

TumCMig, Tumor cell migration: Click to Expand ⟱
Source:
Type:
Tumor cell migration is a critical process in cancer progression and metastasis, which is the spread of cancer cells from the primary tumor to distant sites in the body.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
5868- CA,    Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29 - in-vitro, CRC, LoVo
Apoptosis↑, TumCMig↓, uPA↓, MMPs↓, COX2/PTGS2↓, TumCA↓, MMP9↓, MMP2↓, chemoPv↑,
6301- Cro,    Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways
- vitro+vivo, Colon, HT29 - in-vitro, Colon, Caco-2
tumCV↓, selectivity↑, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, NF-kB↓, VEGF↓, TumMeta↓,
6204- Cuc,    Preliminary investigation of the anti-colon cancer activity of cucurbitacin C from cucumber: A network pharmacological study and experimental validation
- in-vitro, Colon, HCT116
TumCP↓, TumCMig↓, TumCG↓, MMP1↓, MMP3↓, MMP9↓, MMP13↓, Apoptosis↑,
1655- FA,    Ferulic acid inhibiting colon cancer cells at different Duke’s stages
- in-vitro, Colon, SW480 - in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, TumCMig↓, TumCCA↑, Apoptosis↑, ATM↑, Chk2↑, ATR↑, CHK1↑, CK2↓, cycA1/CCNA1↑, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑,
7014- Fuc,  5-FU,    Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, Colon, Caco-2
tumCV↓, ChemoSen↑, TumCCA↑, cl‑PARP↑, KRAS↓, p‑ERK↓, PI3K↓, p‑Akt↓, TumCMig↓, MMP2↓, Dose↝,
7052- Gallo,    Galloflavin Relieves the Malignant Behavior of Colorectal Cancer Cells in the Inflammatory Tumor Microenvironment
- in-vivo, Colon, SW48
TumCMig↓, TumCI↓, NLRP3↓, LDH↓, Inflam↓, IL6↓, TNF-α↓, IL1β↓,
1116- GI,    6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT116
TumCG↓, Apoptosis↑, TumCMig↓, MMP2↓, N-cadherin↓, IKKα↓, p‑NF-kB↓, Snail↓, VEGF↓,
7695- IP6,    The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1β-stimulated colon cancer cells
- in-vitro, Colon, Caco-2
AntiCan↑, TumCA↓, TumCMig↓, MMP13↓, MMP3↓, MMP2↓, TIMP1↓, MMP1↓, MMP9↓, TIMP2↓,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,
1048- RosA,  GSL,    Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis
- in-vivo, Colon, MC38
TumCMig↓, TumCI↓, PD-1↓, COX2/PTGS2↓, PD-L1↓,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

GlucoseCon↓, 1,   LDH↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 2,   Apoptosis↑, 5,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   Chk2↑, 1,   CK2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   ATR↑, 1,   CHK1↑, 1,   P53↑, 2,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycA1/CCNA1↑, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   p‑ERK↓, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   PI3K↓, 2,   p‑PI3K↓, 1,   STAT3↓, 1,   TumCG↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

KRAS↓, 1,   MMP1↓, 2,   MMP13↓, 2,   MMP2↓, 4,   MMP3↓, 2,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 1,   Snail↓, 1,   TIMP1↓, 1,   TIMP2↓, 1,   TumCA↓, 2,   TumCI↓, 5,   TumCMig↓, 11,   TumCP↓, 3,   TumMeta↓, 1,   uPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IKKα↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   p‑NF-kB↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 1,   Dose∅, 1,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   KRAS↓, 1,   LDH↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoPv↑, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 78

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   Half-Life∅, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: TumCMig, Tumor cell migration
1 Apigenin (mainly Parsley)
1 Carnosic acid
1 Crocetin
1 Cucurbitacin
1 Ferulic acid
1 Fucoidan
1 5-fluorouracil
1 Galloflavin
1 Ginger/6-Shogaol/Gingerol
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Isovitexin
1 Rosmarinic acid
1 Germacranolide sesquiterpene lactone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:326  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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