ATF3 Cancer Research Results

ATF3, Activating Transcription Factor 3: Click to Expand ⟱
Source:
Type:
ATF3 (Activating Transcription Factor 3) is a stress‐responsive transcription factor that is frequently induced by various cellular stresses, including DNA damage, oxidative stress, and inflammatory signals.

-Several studies have shown that ATF3 is upregulated in response to cellular stress in breast cancers.
-Increased ATF3 expression has been associated with reduced cell proliferation and invasiveness, suggesting a tumor-suppressive role.

• In some cancers and contexts, elevated ATF3 is linked with apoptosis induction and a favorable prognosis, acting as a tumor suppressor.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
123- CUR,    Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells
- in-vitro, Colon, LoVo - in-vitro, Colon, COLO205 - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
NF-kB↓, ATF3↑, HO-1↑, Wnt↓, Akt↓, mTOR↓, PTEN↑, Apoptosis↑, TGF-β↓, PPARγ↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   HO-1↑, 1,  

Core Metabolism/Glycolysis ⓘ

PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PTEN↑, 1,   Wnt↓, 1,  

Migration ⓘ

TGF-β↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATF3, Activating Transcription Factor 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:1263  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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