miR-339-5p Cancer Research Results

miR-339-5p, MicroRNA-339-5p: Click to Expand ⟱
Source:
Type:

miR-339-5p - MicroRNA-339-5p

Abbreviation: miR-339-5p

Type: MicroRNA / post-transcriptional gene-expression regulator

Function: miR-339-5p is a regulatory microRNA that binds complementary sequences within target mRNAs and suppresses their expression through mRNA degradation and/or translational inhibition. Reported targets include MDM2, BACE1, and other genes involved in proliferation, survival, invasion, and signaling.

Cancer: ↓ Frequently reduced in cancer and predominantly functions as a tumor-suppressive microRNA. miR-339-5p can directly inhibit MDM2, thereby enhancing p53 activity, apoptosis, senescence, and growth arrest. Increased miR-339-5p has also been shown to suppress cancer-cell proliferation, migration, invasion, and tumor growth.

Alzheimer's Disease: ↓ Reduced miR-339-5p has been reported in Alzheimer's disease brain tissue. miR-339-5p directly suppresses BACE1 expression; therefore, loss of miR-339-5p can contribute to increased BACE1 activity and increased amyloidogenic APP processing and Aβ production.

Favorable Direction: ↑ Restoration or increased miR-339-5p activity is generally favorable in both cancer and Alzheimer's disease contexts.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
8092- KAE,    Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells
- in-vitro, Colon, HCT116 - in-vitro, Colon, DLD1
TumCP↓, TumCCA↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, miR-339-5p↑, Glycolysis↓, PKM2↓, PKM1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-339-5p↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   PKM1↑, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-339-5p, MicroRNA-339-5p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:1762  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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