Beclin-1/ATG6 Cancer Research Results

Beclin-1/ATG6, Beclin-1 (BECN1 gene): Click to Expand ⟱
Source:
Type: Protein Coding gene
Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown.
A key biomarker of autophagy is Beclin-1. Beclin-1 stimulates LC3-I’s lipidation to produce LC3-II, which localizes to the autophagosome membrane to activate the development of autophagosomes.
-BECN1 = the official gene symbol (human gene name)
-Beclin-1 = the protein name encoded by the BECN1 gene

BECN1 - Beclin 1

Abbreviation: BECN1, Beclin 1

Alternative Names: ATG6, VPS30

Type: Autophagy regulator / class III PI3K complex component

Function: Beclin 1 is a core component of the VPS34/class III PI3K complex and promotes phosphatidylinositol-3-phosphate production required for autophagosome nucleation and membrane trafficking.

Cancer: ↕ Context-dependent. Reduced BECN1 expression can contribute to tumor initiation and genomic instability, supporting a tumor-suppressive role in some tissues. However, established cancers can also exploit Beclin 1-dependent autophagy for survival under metabolic and therapeutic stress.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
387- AgNPs,    Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells
- in-vitro, Colon, HT-29
Cyt‑c↑, P53↑, BAX↑, Casp3↑, Casp9↑, Casp12↑, Beclin-1/ATG6↑, CHOP/DDIT3↑, LC3s↑, XBP-1↑,
6984- Form,    Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
- in-vitro, Colon, HCT116 - Review, IBD, RAW264.7
*Inflam↓, AntiCan↑, *NF-kB↓, *MAPK↓, *colonLen↑, TumCG↓, Apoptosis↑, LC3II↑, Beclin-1/ATG6↑, cl‑Casp3↑, BAX↑, Bcl-2↓, IGF-1↓, ACLY↓, Acetyl-CoA↓, Fas↓, HSL/LIPE↓, ATGL/PNPLA2↓, FFA/NEFA↓, GSK‐3β↑, p‑mTOR↓, Rictor↓, p‑Akt↓, PDE3B↓, p‑PKA↓, p‑HSL/LIPE↑, TumAuto↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATGL/PNPLA2↓, 1,   FFA/NEFA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   PDE3B↓, 1,   Rictor↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↓, 1,   ACLY↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 2,   Bcl-2↓, 1,   Casp12↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Fas↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3II↑, 1,   LC3s↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↑, 1,   IGF-1↓, 1,   p‑mTOR↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

p‑PKA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 31

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

colonLen↑, 1,  

Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: Beclin-1/ATG6, Beclin-1 (BECN1 gene)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:30  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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