Casp3 Cancer Research Results

Casp3, CPP32, Cysteinyl aspartate specific proteinase-3: Click to Expand ⟱
Source:
Type:
Also known as CP32.
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death.
As a key protein of apoptosis, caspase-3 can also cleave GSDME and induce pyroptosis. Loss of caspase activity is an important cause of tumor progression.
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy.
Caspase 3 is the main effector caspase and has a key role in apoptosis. In many types of cancer, including breast, lung, and colon cancer, caspase-3 expression is reduced or absent.
On the other hand, some studies have shown that high levels of caspase-3 expression can be associated with a better prognosis in certain types of cancer, such as breast cancer. This suggests that caspase-3 may play a role in the elimination of cancer cells, and that therapies aimed at activating caspase-3 may be effective in treating certain types of cancer.
Procaspase-3 is a apoptotic marker protein.
Prognostic significance:
• High Cas3 expression: Associated with good prognosis and increased sensitivity to chemotherapy in breast, gastric, lung, and pancreatic cancers.
• Low Cas3 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
6463- 1,8-Cin,    Antitumor effect of 1, 8-cineole against colon cancer
- vitro+vivo, Colon, HCT116
TumCP↓, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3↑, TumVol↓,
4398- AgNPs,    Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier
- in-vitro, Colon, HT29
Apoptosis↑, MMP↓, Casp3↑, ROS↑, eff↑,
334- AgNPs,    Silver-Based Nanoparticles Induce Apoptosis in Human Colon Cancer Cells Mediated Through P53
- in-vitro, Colon, HCT116
Bax:Bcl2↑, P53↑, P21↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, NF-kB↓, DNAdam↑, TumCCA↑,
387- AgNPs,    Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells
- in-vitro, Colon, HT-29
Cyt‑c↑, P53↑, BAX↑, Casp3↑, Casp9↑, Casp12↑, Beclin-1/ATG6↑, CHOP/DDIT3↑, LC3s↑, XBP-1↑,
304- ALA,    alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation
- in-vitro, Colon, HT-29
mt-ROS↑, Apoptosis↑, Casp3↑, DNAdam↑, Bcl-xL↓, Dose↝,
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
4805- ASTX,    Astaxanthin promotes apoptosis by suppressing growth signaling pathways in HT-29 colorectal cancer cells
- in-vitro, Colon, HT29
TumCP↓, Casp3↑, EGFR↓, HER2/EBBR2↓, ERK↓, Apoptosis↑,
2755- BetA,    Cytotoxic Potential of Betulinic Acid Fatty Esters and Their Liposomal Formulations: Targeting Breast, Colon, and Lung Cancer Cell Lines
- in-vitro, Colon, HT29 - in-vitro, BC, MCF7 - in-vitro, Lung, H460
eff↑, Casp3↑, Casp7↑, NF-kB↓,
5866- CA,    Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
- in-vitro, CRC, HCT116 - in-vitro, Colon, SW480 - in-vitro, Colon, HT29
tumCV↓, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cycD1/CCND1↓, CycD3↓, ROS↑, eff↓, eff↑,
6130- CHr,    Anticancer Properties of Chrysin on Colon Cancer Cells, In vitro and In vivo with Modulation of Caspase-3, -9, Bax and Sall4
- vitro+vivo, Colon, CT26
tumCV↓, Apoptosis↑, TumVol↓, BAX↑, SALL4↓, Casp3↑, Casp9↑, ChemoSen↑, GSH↓,
7416- CS,  Poly,    Phenolic-Rich Extracts from Artichoke By-Products Promote Apoptosis in Human Colorectal Cancer Cell Lines
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29
tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, Apoptosis↑, other↝, eff↑,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
1606- EA,    Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells
- in-vitro, Colon, HCT15
TumCP↓, cycD1/CCND1↓, Apoptosis↑, PI3K↓, Akt↓, ROS↑, Casp3↑, Cyt‑c↑, Bcl-2↓, TumCCA↑, Dose∅, ALP↓, LDH↓, PCNA↓, P53↑, Bax:Bcl2↑,
3208- EGCG,    Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
- in-vitro, Colon, HT29 - in-vitro, Nor, 3T3
TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,
6797- EPA,    Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivo
- in-vivo, Colon, HT29
tumCV↓, Casp3↑, eff↓, eff↑, Apoptosis↑, ROS↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,
6844- EVO,    Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70
- vitro+vivo, Lung, A549 - in-vitro, Colon, HCT116 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Apoptosis↑, CSCs↓, TumVol↓, *toxicity↓, HSP70/HSPA5↓, OCT4↓, Nanog↓, cl‑PARP↑, cl‑Casp3↑,
6839- EVO,    Activation of JNK Contributes to Evodiamine-Induced Apoptosis and G2/M Arrest in Human Colorectal Carcinoma Cells: A Structure-Activity Study of Evodiamine
- in-vitro, CRC, COLO205 - in-vitro, Colon, HT29
tumCV↓, cl‑Casp3↑, PARP↑, MMP↓, BAX↑, Casp9↑, Cyt‑c↑, TumCCA↑, JNK↑,
2856- FIS,    N -acetyl- L -cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells
- in-vitro, Colon, COLO205
eff↑, ROS↑, tumCV↓, Casp3↑, Bcl-2↓, MMP↓, eff↑,
2859- FIS,    The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways
- in-vitro, Liver, HepG2 - NA, Colon, Caco-2
TumCG↓, other↝, Casp3↑, Casp7↑, PGE2↓, GSTs↓, Wnt↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, P53↑, P21↑, P450↓,
6984- Form,    Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
- in-vitro, Colon, HCT116 - Review, IBD, RAW264.7
*Inflam↓, AntiCan↑, *NF-kB↓, *MAPK↓, *colonLen↑, TumCG↓, Apoptosis↑, LC3II↑, Beclin-1/ATG6↑, cl‑Casp3↑, BAX↑, Bcl-2↓, IGF-1↓, ACLY↓, Acetyl-CoA↓, Fas↓, HSL/LIPE↓, ATGL/PNPLA2↓, FFA/NEFA↓, GSK‐3β↑, p‑mTOR↓, Rictor↓, p‑Akt↓, PDE3B↓, p‑PKA↓, p‑HSL/LIPE↑, TumAuto↑,
7555- HYP,  RT,    Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells
- in-vitro, Colon, HT29
tumCV↓, Apoptosis↑, BAX↑, Bcl-2↓, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑,
2177- itraC,    Itraconazole improves survival outcomes in patients with colon cancer by inducing autophagic cell death and inhibiting transketolase expression
- Study, Colon, NA - in-vitro, CRC, COLO205 - in-vitro, CRC, HCT116
OS↑, tumCV↓, Casp3↑, TumCCA↑, HH↓, TumAuto↑, LC3B↑, p62↑, TKT↓,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,
2915- LT,    Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- in-vitro, Colon, HT29 - in-vitro, CRC, SNU-407 - in-vitro, Nor, FHC
DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,
64- QC,    Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW-620 - in-vitro, Colon, Caco-2
Cyt‑c↑, BAX↑, Casp3↑, DR4↑, DR5↑,
104- RES,  QC,    Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a
- in-vitro, Colon, HT-29
Casp3↑, PARP↑, survivin↓, miR-27a-3p↓, Sp1/3/4↓, ZBTB10↑, ROS⇅, TAC↑, tumCV↓,
1474- SFN,    Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway
- in-vitro, Colon, SW480
TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,
628- VitC,  Mg,    Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation
- in-vivo, Colon, CT26 - in-vitro, NA, MCF7 - in-vitro, NA, SkBr3
AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,

Showing Research Papers: 1 to 29 of 29

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 29

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATGL/PNPLA2↓, 1,   FFA/NEFA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   PDE3B↓, 1,   Rictor↓, 1,   SALL4↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Catalase↑, 1,   GSH↓, 2,   GSS↑, 1,   GSTs↓, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 9,   ROS⇅, 1,   mt-ROS↑, 1,   TAC↑, 1,   TKT↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↓, 1,   ACLY↓, 1,   GlucoseCon↓, 1,   LDH↓, 1,   LDH↑, 1,   NAD↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 16,   BAD↑, 1,   BAX↑, 12,   Bax:Bcl2↑, 4,   Bcl-2↓, 10,   Bcl-xL↓, 3,   Casp12↑, 1,   Casp3↑, 23,   cl‑Casp3↑, 5,   proCasp3↑, 1,   Casp7↑, 4,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 9,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 4,   DR4↑, 1,   DR5↑, 1,   Fas↓, 1,   JNK↑, 1,   MAPK↓, 1,   MDM2↓, 1,   p27/CDKN1B↑, 1,   p38↑, 2,   survivin↓, 3,   TumCD↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-27a-3p↓, 1,   other↝, 2,   TET3↑, 1,   tumCV↓, 10,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3B↑, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   P53↑, 9,   P53∅, 1,   PARP↑, 2,   cl‑PARP↑, 6,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   CycD3↓, 1,   P21↑, 6,   TumCCA↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 3,   ERK↓, 1,   e-ERK↑, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   HH↓, 1,   IGF-1↓, 1,   mTOR↓, 2,   p‑mTOR↓, 2,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 3,   p‑PI3K↓, 1,   STAT3↓, 2,   TumCG↓, 3,   Wnt↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   p‑PKA↓, 1,   Slug↓, 1,   Snail↓, 1,   TET1↑, 2,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 4,   TumMeta↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 1,   EGFR↓, 2,   Hif1a↓, 1,   VEGF↓, 1,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   SVCT-2↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↑, 1,   Inflam↓, 1,   NF-kB↓, 4,   PGE2↓, 2,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 3,   Dose↝, 1,   Dose∅, 2,   eff↓, 4,   eff↑, 7,   Half-Life↓, 1,   P450↓, 1,   selectivity↑, 4,   TET2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1,   EGFR↓, 2,   HER2/EBBR2↓, 1,   Ki-67↓, 1,   LDH↓, 1,   LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   OS↑, 1,   TumVol↓, 5,   TumW↓, 1,  
Total Targets: 164

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

colonLen↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSTs↑, 1,   RNS↓, 1,   ROS↓, 1,   SOD↓, 1,  

Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   Half-Life∅, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,   toxicity↓, 2,   toxicity∅, 1,  
Total Targets: 16

Scientific Paper Hit Count for: Casp3, CPP32, Cysteinyl aspartate specific proteinase-3
3 Silver-NanoParticles
2 Evodiamine
2 Fisetin
2 Quercetin
1 1,8-Cineole
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 Betulinic acid
1 Carnosic acid
1 Chrysin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Polyphenols
1 D-limonene
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 eicosapentaenoic acid
1 Eugenol
1 Formononetin
1 Hyperoside
1 Rutin
1 itraconazole
1 Isovitexin
1 Luteolin
1 Resveratrol
1 Sulforaphane (mainly Broccoli)
1 Vitamin C (Ascorbic Acid)
1 Magnesium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:42  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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