PUMA Cancer Research Results
PUMA, p53 upregulated modulator of apoptosis: Click to Expand ⟱
| Source: |
| Type: pro-apoptotic protein |
The expression of PUMA is regulated by the tumor suppressor p53.
PUMA serves as an important proapoptotic factor that functions as a tumor suppressor by facilitating the elimination of damaged or aberrant cells. In many cancers, impaired induction of PUMA—often due to p53 dysfunction—correlates with treatment resistance and aggressive disease.
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Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
GBM, |
A172 |
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in-vitro, |
Colon, |
Caco-2 |
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in-vitro, |
Pca, |
DU145 |
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in-vitro, |
BC, |
MCF-7 |
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in-vitro, |
Nor, |
L929 |
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*BioAv↑, selectivity↑, AntiCan↑, Apoptosis↑, CHOP↑, GADD34↑, BIM↑, PUMA↑, Ca+2↝,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death ⓘ
Apoptosis↑, 1, BIM↑, 1, GADD34↑, 1, PUMA↑, 1,
Protein Folding & ER Stress ⓘ
CHOP↑, 1,
Migration ⓘ
Ca+2↝, 1,
Drug Metabolism & Resistance ⓘ
selectivity↑, 1,
Functional Outcomes ⓘ
AntiCan↑, 1,
Total Targets: 8
Pathway results for Effect on Normal Cells:
Drug Metabolism & Resistance ⓘ
BioAv↑, 1,
Total Targets: 1
Scientific Paper Hit Count for: PUMA, p53 upregulated modulator of apoptosis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:31 Cells:% prod#:% Target#:430 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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