Casp8 Cancer Research Results
Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱
| Source: CGL-Driver Genes |
| Type: TSG |
Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.
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Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
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Scientific Papers found: Click to Expand⟱
| - |
in-vitro, |
Colon, |
HCT116 |
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Bax:Bcl2↑, P53↑, P21↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, NF-kB↓, DNAdam↑, TumCCA↑,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death ⓘ
Akt↓, 1, Bax:Bcl2↑, 1, Casp3↑, 1, Casp8↑, 1, Casp9↑, 1,
DNA Damage & Repair ⓘ
DNAdam↑, 1, P53↑, 1,
Cell Cycle & Senescence ⓘ
P21↑, 1, TumCCA↑, 1,
Immune & Inflammatory Signaling ⓘ
NF-kB↓, 1,
Total Targets: 10
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:31 Cells:% prod#:% Target#:44 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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