ZBTB10 Cancer Research Results

ZBTB10, ZBTB transcription Factor 10: Click to Expand ⟱
Source:
Type:
ZBTB10, which was an important target of miR-27a, suppressed the expression of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR1), VEGFR2 and survivin which were responsible for angiogenesis and metastasis of cancer.

Downregulation of ZBTB10 has been noted in contexts where high miR-27a expression suppresses its levels, indirectly leading to the upregulation of genes that promote tumor progression. Lower levels of ZBTB10 have been associated in some studies with more aggressive tumor behavior and poorer prognosis.
– The rationale is that reduced ZBTB10 expression may lead to unchecked Sp1 activity, driving the expression of pro-tumorigenic genes involved in proliferation, angiogenesis, and survival.

Current evidence suggests that ZBTB10 may function as a tumor suppressor by inhibiting Sp1-dependent oncogenic pathways. In several cancers, reduced expression of ZBTB10—often driven by microRNA-mediated repression—correlates with enhanced tumor progression and poorer outcomes.


Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
104- RES,  QC,    Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a
- in-vitro, Colon, HT-29
Casp3↑, PARP↑, survivin↓, miR-27a-3p↓, Sp1/3/4↓, ZBTB10↑, ROS⇅, TAC↑, tumCV↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS⇅, 1,   TAC↑, 1,  

Cell Death ⓘ

Casp3↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

miR-27a-3p↓, 1,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

PARP↑, 1,  

Angiogenesis & Vasculature ⓘ

ZBTB10↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ZBTB10, ZBTB transcription Factor 10
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:505  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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