XBP-1 Cancer Research Results

XBP-1, X-box binding protein 1: Click to Expand ⟱
Source:
Type:
XBP-1 (X-box binding protein 1) is a transcription factor that plays a crucial role in the unfolded protein response (UPR).
XBP-1 is activated in response to endoplasmic reticulum (ER) stress, which occurs when the ER is overwhelmed with unfolded or misfolded proteins.
XBP-1 has been shown to have both tumor-promoting and tumor-suppressing roles.
XBP-1 is overexpressed in various types of cancer, including breast, lung, colon, and pancreatic cancer. In some cases, XBP-1 overexpression has been associated with poor prognosis and reduced survival rates.
Targeting XBP-1 and the UPR has been proposed as a potential therapeutic strategy for cancer treatment. Inhibitors of XBP-1 or other UPR components may be able to selectively kill cancer cells that are under ER stress, while sparing normal cells.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
387- AgNPs,    Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells
- in-vitro, Colon, HT-29
Cyt‑c↑, P53↑, BAX↑, Casp3↑, Casp9↑, Casp12↑, Beclin-1↑, CHOP↑, LC3s↑, XBP-1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↑, 1,   Casp12↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3s↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: XBP-1, X-box binding protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:631  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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